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Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
To
investigate
the
clinical
prognostic
value
of
protein
tyrosine
kinase
6
(
PTK
6
)
in
patients
with
esophageal
squamous
cell
carcinoma
(
ESCC
)
,
quantitative
RT-PCR
and
Western
blotting
were
utilized
to
measure
the
mRNA
and
protein
expression
levels
of
PTK
6
in
29
and
eight
pairs
of
ESCC
and
peritumoral
normal
esophageal
tissues
,
respectively
.
Furthermore
,
the
expression
of
PTK
6
protein
in
210
ESCCs
was
examined
with
immunohistochemistry
(
IHC
)
,
and
its
clinical
value
was
analyzed
using
Kaplan-
Meier
plots
and
the
Cox
proportional
hazards
regression
model
.
The
results
found
that
the
expression
levels
of
both
PTK
6
mRNA
and
protein
in
ESCC
tissues
were
significantly
lower
than
those
in
peritumoral
normal
esophageal
tissues
.
Regarding
the
IHC
analysis
of
ESCC
,
the
cytoplasmic
expression
of
PTK
6
was
significantly
correlated
with
tumor
grade
(
P
<
0
.
001
)
.
Compared
with
patients
with
low
PTK
6
expression
,
ESCC
patients
with
overexpression
of
PTK
6
displayed
preferable
disease-free
survival
(
DFS
)
and
overall
survival
(
OS
)
(
P
<
0
.
001
and
P
=
0
.
001
,
respectively
)
,
especially
in
stage
II
disease
(
P
=
0
.
002
and
P
=
0
.
021
,
respectively
)
.
PTK
6
was
evaluated
as
an
independent
prognostic
factor
for
ESCC
using
multivariate
Cox
regression
analysis
.
All
data
demonstrated
that
the
expression
level
of
PTK
6
is
an
independent
prognostic
factor
in
ESCCs
.
Low
expression
of
PTK
6
is
correlated
with
poor
DFS
and
OS
in
ESCCs
.
