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The influence of elevated levels of C-reactive protein and hypoalbuminemia on survival in patients with advanced inoperable esophageal cancer undergoing palliative treatment.
[esophageal carcinoma]
Inflammation
perpetuates
individual
tumor
progression
resulting
in
decreased
survival
in
cancer
patients
.
The
aim
of
our
study
was
to
evaluate
the
influence
of
elevated
levels
of
C-
reactive
protein
(
CRP
)
as
well
as
low
levels
of
albumin
on
patients
with
inoperable
esophageal
carcinoma
.
The
data
of
218
patients
with
advanced
esophageal
cancer
,
who
were
treated
at
a
single
center
within
12
years
,
were
evaluated
retrospectively
.
Patient
's
age
,
gender
,
body
weight
,
dysphagia
,
plasma
levels
of
CRP
and
albumin
,
the
Glasgow
Prognostic
Score
(
GPS
)
combining
both
indicators
,
and
survival
were
assessed
for
statistical
evaluation
.
Thirty
-
nine
(
18
.
2
%
)
had
hypoalbuminemia
and
161
(
73
.
9
%
)
had
elevated
CRP
levels
.
Patients
with
hypoalbuminemia
(
P
=
0
.
001
)
as
well
as
patients
with
increased
CRP
levels
(
P
=
0
.
001
)
showed
a
significantly
shorter
survival
.
Weight
loss
was
correlated
to
elevated
plasma
CRP
(
P
=
0
.
022
)
,
to
diarrhea
(
P
=
0
.
021
)
,
and
to
dysphagia
(
P
=
0
.
008
)
.
Increasing
GPS
was
significantly
associated
with
poor
survival
(
P
=
0
.
001
)
.
Elevated
CRP
levels
and
hypoalbuminemia
are
significantly
associated
with
reduced
survival
and
are
considered
to
be
an
appropriate
predictor
for
poor
outcome
in
advanced
esophageal
carcinoma
.
The
GPS
provides
additional
detailed
prognostication
and
should
be
therefore
taken
into
consideration
when
the
individual
palliative
strategy
has
to
be
scheduled
.
J
.
Surg
.
Oncol
.
2014
110
:
645
-
650
.
©
2014
Wiley
Periodicals
,
Inc
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated