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Inhibition of human esophageal squamous cell carcinomas by targeted silencing of tumor enhancer genes: an overview.
[esophageal carcinoma]
Esophageal
cancer
has
been
reported
as
the
ninth
most
common
malignancy
and
ranks
as
the
sixth
most
frequent
cause
of
death
worldwide
.
Esophageal
cancer
treatment
involves
surgery
,
chemotherapy
,
radiation
therapy
,
or
combination
therapy
.
Novel
strategies
are
needed
to
boost
the
oncologic
outcome
.
Recent
advances
in
the
molecular
biology
of
esophageal
cancer
have
documented
the
role
of
genetic
alterations
in
tumorigenesis
.
Oncogenes
serve
a
pivotal
function
in
tumorigenesis
.
Targeted
therapies
are
directed
at
the
unique
molecular
signature
of
cancer
cells
for
enhanced
efficacy
with
low
toxicity
.
RNA
interference
(
RNAi
)
technology
is
a
powerful
tool
for
silencing
endogenous
or
exogenous
genes
in
mammalian
cells
.
Related
results
have
shown
that
targeting
oncogenes
with
siRNAs
,
specifically
the
mRNA
,
effectively
reduces
tumor
cell
proliferation
and
induces
apoptotic
cell
death
.
This
article
will
briefly
review
studies
on
silencing
tumor
enhancer
genes
related
to
the
induction
of
esophageal
cancer
.
Diseases
Validation
Diseases presenting
"tumor cell proliferation"
symptom
adrenal incidentaloma
cholangiocarcinoma
esophageal carcinoma
hodgkin lymphoma, classical
kallmann syndrome
severe combined immunodeficiency
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