Rare Diseases Symptoms Automatic Extraction
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Determination of internal target volume for radiation treatment planning of esophageal cancer by using 4-dimensional computed tomography (4DCT).
[esophageal carcinoma]
To
determine
an
efficient
strategy
for
the
generation
of
the
internal
target
volume
(
ITV
)
for
radiation
treatment
planning
for
esophageal
cancer
using
4
-
dimensional
computed
tomography
(
4
DCT
)
.
4
DCT
sets
acquired
for
20
patients
with
esophageal
carcinoma
were
analyzed
.
Each
of
the
4
DCT
sets
was
binned
into
10
respiratory
phases
.
For
each
patient
,
the
gross
tumor
volume
(
GTV
)
was
delineated
on
the
4
DCT
set
at
each
phase
.
Various
strategies
to
derive
ITV
were
explored
,
including
the
volume
from
the
maximum
intensity
projection
(
MIP
;
ITV
_
MIP
)
,
unions
of
the
GTVs
from
selected
multiple
phases
ITV
2
(
0
%
and
50
%
phases
)
,
ITV
3
(
ITV
2
plus
80
%
)
,
and
ITV
4
(
ITV
3
plus
60
%
)
,
as
well
as
the
volumes
expanded
from
ITV
2
and
ITV
3
with
a
uniform
margin
.
These
ITVs
were
compared
to
ITV
10
(
the
union
of
the
GTVs
for
all
10
phases
)
and
the
differences
were
measured
with
the
overlap
ratio
(
OR
)
and
relative
volume
ratio
(
RVR
)
relative
to
ITV
10
(
ITVx
/
ITV
10
)
.
For
all
patients
studied
,
the
average
GTV
from
a
single
phase
was
84
.
9
%
of
ITV
10
.
The
average
ORs
were
91
.
2
%
,
91
.
3
%
,
94
.
5
%
,
and
96
.
4
%
for
ITV
_
MIP
,
ITV
2
,
ITV
3
,
and
ITV
4
,
respectively
.
Low
ORs
were
associated
with
irregular
breathing
patterns
.
ITV
3
s
plus
1
mm
uniform
margins
(
ITV
3
+
1
)
led
to
an
average
OR
of
98
.
1
%
and
an
average
RVR
of
106
.
4
%
.
The
ITV
generated
directly
from
MIP
underestimates
the
range
of
the
respiration
motion
for
esophageal
cancer
.
The
ITV
generated
from
3
phases
(
ITV
3
)
may
be
used
for
regular
breathers
,
whereas
the
ITV
generated
from
4
phases
(
ITV
4
)
or
ITV
3
plus
a
1
-
mm
uniform
margin
may
be
applied
for
irregular
breathers
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated