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Expression of BAG-1 is closely related to cell differentiation and TNM stage in esophageal cancer and its downregulation inhibits the proliferation and invasion of human esophageal carcinoma cells.
[esophageal carcinoma]
The
aim
of
the
present
study
was
to
explore
the
correlation
of
BAG-
1
with
clinical
characteristics
of
esophageal
cancer
and
its
effects
on
the
proliferation
,
invasion
and
apoptosis
of
the
esophageal
carcinoma
cell
line
Eca
109
.
Therefore
,
the
expression
of
BAG-
1
was
assessed
in
esophageal
carcinoma
tumor
tissues
and
adjacent
normal
esophageal
tissues
.
The
siRNA
vector
of
BAG-
1
was
constructed
and
transfected
into
the
Eca
109
cell
line
,
and
then
fluorescence
microscopy
was
used
to
evaluate
the
transfection
efficiency
.
MTT
and
Transwell
assays
were
used
to
study
cell
proliferation
and
invasive
activity
,
and
the
apoptosis
rate
was
assessed
by
flow
cytometry
.
Western
blotting
was
adopted
to
assess
the
silencing
efficiency
and
expression
of
related
gene
bcl-
2
.
The
results
revealed
that
BAG-
1
expression
was
low
in
the
adjacent
normal
esophageal
tissues
while
expression
was
high
in
the
esophageal
carcinoma
tissues
.
After
Eca
109
cells
were
transfected
with
BAG-
1
-
siRNA
,
the
proliferation
and
invasive
capabilities
of
the
cells
were
significantly
decreased
while
the
apoptosis
rate
was
greatly
enhanced
(
P
<
0
.
01
)
.
When
the
expression
of
BAG-
1
in
the
Eca
109
cells
was
downregulated
,
the
expression
of
bcl-
2
was
significantly
abated
(
P
<
0
.
05
)
.
In
conclusion
,
BAG-
1
is
closely
connected
with
the
pathogenesis
and
development
of
esophageal
carcinoma
,
which
may
act
through
affecting
bcl-
2
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
