Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang.
[esophageal carcinoma]
This
study
aimed
to
explore
some
useful
biomarkers
to
focus
on
the
diagnosis
and
therapy
response
judgment
in
esophageal
squamous
cell
carcinoma
in
Xinjiang
.
We
used
enzyme-linked
immunosorbent
method
and
immunohistochemistry
to
detect
the
expression
of
VEGF
,
EGFR
,
ES
,
HER-
2
,
and
NF-κBp
in
the
serum
and
tissue
with
esophageal
squamous
cell
carcinoma
,
and
to
analyze
the
relationship
between
biomarkers
and
clinical
pathology
and
curative
effects
.
Our
findings
were
as
follows
:
1
.
The
serum
levels
of
VEGF
and
ES
in
Han
patients
were
obviously
higher
than
those
of
Uygur
and
Kazakh
patients
(
P
<
0
.
05
)
.
The
VEGF
positive
rate
in
patients
at
a
later
clinical
stage
was
higher
than
that
of
the
patients
at
an
earlier
clinical
stage
(
stages
II
-IV
were
14
.
29
,
50
.
00
,
and
50
.
00
%
,
respectively
,
P
<
0
.
05
)
,
meanwhile
it
was
higher
than
that
of
patients
without
lymph
node
metastases
(
78
.
13
vs
25
.
00
%
,
P
<
0
.
05
)
.
The
curative
effective
rate
of
patients
with
negative
expression
of
VEGF
was
higher
than
that
of
patients
with
positive
expression
of
VEGF
(
74
.
67
vs
41
.
40
%
,
P
<
0
.
05
)
.
2
.
The
expression
of
EGFR
protein
in
male
patients
was
higher
than
that
of
female
patients
(
69
.
77
vs
35
.
29
%
,
P
<
0
.
05
)
.
Before
treatment
,
the
serum
EGFR
level
in
patients
was
higher
than
the
normal
group
(
P
<
0
.
05
)
.
3
.
The
serum
ES
level
in
patients
before
and
after
treatment
was
significantly
higher
than
in
the
normal
group
(
P
<
0
.
05
)
.
4
.
The
HER-
2
positive
rate
in
higher
differentiated
tumor
tissue
was
lower
than
that
in
lower
differentiated
tumor
tissue
.
(
The
positive
rate
of
I
,
II
,
III
grade
was
70
.
00
,
30
.
00
,
and
20
.
00
%
,
respectively
,
P
<
0
.
05
)
.
5
.
The
NF-κB
positive
rate
in
patients
with
lymph
node
metastases
was
higher
than
that
of
patients
without
lymph
node
metastases
(
65
.
63
vs
39
.
27
%
,
P
<
0
.
05
)
,
meanwhile
median
survival
in
the
latter
group
was
higher
than
that
of
the
former
group
(
P
<
0
.
05
)
.
Our
data
suggest
that
the
expression
of
VEGF
and
ES
were
different
in
Uygur
,
Han
,
and
Kazakh
patients
in
Xinjiang
.
The
combined
detection
of
tumor
markers
in
serum
and
tissue
is
of
direct
significance
for
tumor
therapy
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated