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Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang.
[esophageal carcinoma]
This
study
aimed
to
explore
some
useful
biomarkers
to
focus
on
the
diagnosis
and
therapy
response
judgment
in
esophageal
squamous
cell
carcinoma
in
Xinjiang
.
We
used
enzyme-linked
immunosorbent
method
and
immunohistochemistry
to
detect
the
expression
of
VEGF
,
EGFR
,
ES
,
HER-
2
,
and
NF-κBp
in
the
serum
and
tissue
with
esophageal
squamous
cell
carcinoma
,
and
to
analyze
the
relationship
between
biomarkers
and
clinical
pathology
and
curative
effects
.
Our
findings
were
as
follows
:
1
.
The
serum
levels
of
VEGF
and
ES
in
Han
patients
were
obviously
higher
than
those
of
Uygur
and
Kazakh
patients
(
P
<
0
.
05
)
.
The
VEGF
positive
rate
in
patients
at
a
later
clinical
stage
was
higher
than
that
of
the
patients
at
an
earlier
clinical
stage
(
stages
II
-IV
were
14
.
29
,
50
.
00
,
and
50
.
00
%
,
respectively
,
P
<
0
.
05
)
,
meanwhile
it
was
higher
than
that
of
patients
without
lymph
node
metastases
(
78
.
13
vs
25
.
00
%
,
P
<
0
.
05
)
.
The
curative
effective
rate
of
patients
with
negative
expression
of
VEGF
was
higher
than
that
of
patients
with
positive
expression
of
VEGF
(
74
.
67
vs
41
.
40
%
,
P
<
0
.
05
)
.
2
.
The
expression
of
EGFR
protein
in
male
patients
was
higher
than
that
of
female
patients
(
69
.
77
vs
35
.
29
%
,
P
<
0
.
05
)
.
Before
treatment
,
the
serum
EGFR
level
in
patients
was
higher
than
the
normal
group
(
P
<
0
.
05
)
.
3
.
The
serum
ES
level
in
patients
before
and
after
treatment
was
significantly
higher
than
in
the
normal
group
(
P
<
0
.
05
)
.
4
.
The
HER-
2
positive
rate
in
higher
differentiated
tumor
tissue
was
lower
than
that
in
lower
differentiated
tumor
tissue
.
(
The
positive
rate
of
I
,
II
,
III
grade
was
70
.
00
,
30
.
00
,
and
20
.
00
%
,
respectively
,
P
<
0
.
05
)
.
5
.
The
NF-κB
positive
rate
in
patients
with
lymph
node
metastases
was
higher
than
that
of
patients
without
lymph
node
metastases
(
65
.
63
vs
39
.
27
%
,
P
<
0
.
05
)
,
meanwhile
median
survival
in
the
latter
group
was
higher
than
that
of
the
former
group
(
P
<
0
.
05
)
.
Our
data
suggest
that
the
expression
of
VEGF
and
ES
were
different
in
Uygur
,
Han
,
and
Kazakh
patients
in
Xinjiang
.
The
combined
detection
of
tumor
markers
in
serum
and
tissue
is
of
direct
significance
for
tumor
therapy
.
Diseases
Validation
Diseases presenting
"meanwhile median survival in the latter group"
symptom
esophageal carcinoma
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