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Prognostic factors in patients with recurrence after complete resection of esophageal squamous cell carcinoma.
[esophageal carcinoma]
Recurrence
following
complete
resection
of
esophageal
squamous
cell
carcinoma
(
SCC
)
still
remains
common
.
The
aim
of
this
study
was
to
investigate
the
prognostic
factors
in
patients
with
recurrence
after
complete
resection
of
esophageal
SCC
.
The
medical
records
of
190
patients
with
recurrent
disease
after
complete
resection
of
esophageal
SCC
were
retrospectively
reviewed
.
Recurrence
pattern
was
classified
as
loco-regional
recurrence
and
distant
metastases
.
The
Kaplan-
Meier
method
was
used
for
the
survival
analysis
.
Cox
proportional
hazards
model
was
used
for
multivariate
analysis
.
Mediastinal
nodal
clearance
area
was
the
most
common
sites
of
loco-regional
recurrence
,
whereas
lung
,
liver
and
bone
were
the
most
common
sites
for
distant
metastases
.
The
median
survival
after
recurrence
was
8
months
.
The
1
,
3
,
5
-
year
post-recurrence
survival
rates
were
45
.
9
%
,
10
.
6
%
and
6
.
4
%
,
respectively
.
The
overall
1
,
3
,
5
-
year
survival
rates
were
76
.
6
%
,
27
.
3
%
and
12
.
3
%
,
respectively
.
The
independent
prognostic
factors
included
time
of
recurrence
(
≥
12
months
vs
.
<
12
months
,
HR
:
3
.
228
,
95
%
CI
:
2
.
233
-
4
.
668
)
,
pattern
of
recurrence
(
local-regional
recurrence
vs
.
distant
metastases
,
HR
:
1
.
690
,
95
%
CI
:
1
.
170
-
2
.
439
)
,
and
treatment
of
recurrence
[
no
treatment
vs
.
treatment
(
radiotherapy
or
surgery
or
chemotherapy
)
,
HR
:
0
.
642
,
95
%
CI
:
0
.
458
-
0
.
899
]
.
Our
retrospective
study
showed
that
time
of
recurrence
,
pattern
of
recurrence
and
treatment
of
recurrence
were
independent
prognostic
factors
in
patients
with
recurrence
after
complete
resection
of
esophageal
SCC
.
Diseases
Validation
Diseases presenting
"independent prognostic factors in patients"
symptom
esophageal carcinoma
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