Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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RNAi screening identifies HAT1 as a potential drug target in esophageal squamous cell carcinoma.
[esophageal carcinoma]
Esophageal
carcinoma
(
EC
)
is
one
of
the
most
fatal
carcinomas
of
the
gastrointestinal
tract
.
Aberrant
activity
of
histone
acetyltransferases
(
HATs
)
/
deacetylases
(
HDACs
)
play
a
critical
role
in
carcinogenesis
through
the
regulation
of
the
genes
involved
in
cell
differentiation
,
proliferation
,
and
apoptosis
.
However
,
cellular
functions
of
HATs
/
HDACs
in
esophageal
cancer
and
its
molecular
mechanisms
remain
unclear
.
An
RNAi
screen
was
used
in
this
study
to
identify
the
histone
acetyltransferases
(
HATs
)
and
deacetylases
(
HDACs
)
that
could
be
critical
for
the
survival
of
EC
cells
.
We
demonstrated
that
HAT
1
(
histone
acetyltransferase
1
)
was
an
important
determinant
to
regulate
the
proliferation
of
human
EC
Eca-
109
cells
.
Furthermore
,
we
showed
that
the
knockdown
of
HAT
1
induced
a
G
2
/
M
cell
cycle
arrest
,
which
was
associated
with
the
disruption
of
cell
cycle-related
events
,
including
the
decrease
of
cyclinD
1
as
well
as
alteration
in
cyclinB
1
expression
.
The
expression
of
HAT
1
was
validated
to
be
higher
in
the
primary
tumors
and
adjacent
tissue
as
compared
to
that
of
the
normal
esophageal
tissue
.
Furthermore
,
we
found
that
HAT
1
expression
was
directly
correlated
with
the
poor
tumor
differentiation
of
EC
tissue
,
which
suggested
that
HAT
1
played
an
important
role
in
esophageal
carcinoma
and
that
it
could
be
a
novel
EC
therapeutic
target
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
