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Our Team
[Expressions of Dab2 and ERK1 in esophageal carcinoma tissues and their clinical significance].
[esophageal carcinoma]
To
explore
the
expressions
of
protein
and
mRNA
of
disabled-
2
(
Dab
2
)
and
extracellular
signal-regulated
kinase
1
(
ERK
1
)
in
esophageal
squamous
cell
carcinoma
tissue
(
ESCC
)
and
their
clinical
significance
.
The
expressions
of
protein
and
mRNA
of
Dab
2
and
ERK
1
were
detected
in
ESCC
(
n
=
59
)
,
atypical
hyperplasia
(
n
=
27
)
and
normal
esophageal
mucosa
(
n
=
36
)
tissues
by
immunohistochemistry
,
in
situ
hybridization
and
reverse
transcription
polymerase
chain
reaction
(
RT-PCR
)
.
The
expressions
of
protein
and
mRNA
of
Dab
2
were
lesser
in
ESCC
than
those
in
atypical
hyperplasia
and
normal
esophageal
mucosa
tissues
(
23
.
7
%
vs
94
.
4
%
,
44
.
4
%
and
18
.
6
%
vs
97
.
2
%
,
33
.
3
%
)
.
And
the
expressions
of
protein
and
mRNA
ERK
1
were
higher
in
ESCC
than
those
in
atypical
hyperplasia
and
normal
esophageal
mucosa
tissues
(
81
.
4
%
vs
44
.
4
%
,
63
.
0
%
and
78
.
0
%
vs
30
.
6
%
,
51
.
9
%
)
(
all
P
<
0
.
05
)
.
Additionally
,
the
expressions
of
protein
and
mRNA
of
Dab
2
and
ERK
1
were
closely
related
with
lymph
node
metastasis
in
ESCC
tissue
and
the
expressions
of
protein
and
mRNA
of
ERK
1
closely
related
with
the
depth
of
tumor
invasion
in
ESCC
tissue
(
all
P
<
0
.
05
)
.
Furthermore
,
the
results
of
correlation
analysis
revealed
that
expressions
of
protein
and
mRNA
of
Dab
2
and
ERK
1
in
ESCC
had
a
negative
correlation
(
all
P
<
0
.
05
)
.
The
expressions
of
protein
and
mRNA
of
Dab
2
and
ERK
1
play
important
roles
in
the
infiltration
,
metastasis
and
carcinogenesis
of
ESCC
and
their
effects
may
be
antagonistic
to
each
other
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated