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[Expressions of Dab2 and ERK1 in esophageal carcinoma tissues and their clinical significance].
[esophageal carcinoma]
To
explore
the
expressions
of
protein
and
mRNA
of
disabled-
2
(
Dab
2
)
and
extracellular
signal-regulated
kinase
1
(
ERK
1
)
in
esophageal
squamous
cell
carcinoma
tissue
(
ESCC
)
and
their
clinical
significance
.
The
expressions
of
protein
and
mRNA
of
Dab
2
and
ERK
1
were
detected
in
ESCC
(
n
=
59
)
,
atypical
hyperplasia
(
n
=
27
)
and
normal
esophageal
mucosa
(
n
=
36
)
tissues
by
immunohistochemistry
,
in
situ
hybridization
and
reverse
transcription
polymerase
chain
reaction
(
RT-PCR
)
.
The
expressions
of
protein
and
mRNA
of
Dab
2
were
lesser
in
ESCC
than
those
in
atypical
hyperplasia
and
normal
esophageal
mucosa
tissues
(
23
.
7
%
vs
94
.
4
%
,
44
.
4
%
and
18
.
6
%
vs
97
.
2
%
,
33
.
3
%
)
.
And
the
expressions
of
protein
and
mRNA
ERK
1
were
higher
in
ESCC
than
those
in
atypical
hyperplasia
and
normal
esophageal
mucosa
tissues
(
81
.
4
%
vs
44
.
4
%
,
63
.
0
%
and
78
.
0
%
vs
30
.
6
%
,
51
.
9
%
)
(
all
P
<
0
.
05
)
.
Additionally
,
the
expressions
of
protein
and
mRNA
of
Dab
2
and
ERK
1
were
closely
related
with
lymph
node
metastasis
in
ESCC
tissue
and
the
expressions
of
protein
and
mRNA
of
ERK
1
closely
related
with
the
depth
of
tumor
invasion
in
ESCC
tissue
(
all
P
<
0
.
05
)
.
Furthermore
,
the
results
of
correlation
analysis
revealed
that
expressions
of
protein
and
mRNA
of
Dab
2
and
ERK
1
in
ESCC
had
a
negative
correlation
(
all
P
<
0
.
05
)
.
The
expressions
of
protein
and
mRNA
of
Dab
2
and
ERK
1
play
important
roles
in
the
infiltration
,
metastasis
and
carcinogenesis
of
ESCC
and
their
effects
may
be
antagonistic
to
each
other
.
