Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Clinical staging of patients with early esophageal adenocarcinoma: does FDG-PET/CT have a role?
[esophageal carcinoma]
Esophageal
carcinoma
is
a
significant
worldwide
health
problem
and
the
incidence
is
increasing
faster
than
that
of
any
other
malignancy
.
18
F-
2
-
deoxy-
D-
glucose
(
FDG
)
-
positron
emission
tomography
/
computed
tomography
(
PET
/
CT
)
is
important
in
the
management
of
patients
with
potentially
resectable
esophageal
cancer
and
is
useful
in
initial
staging
of
locally
advanced
cancer
and
after
neoadjuvant
therapy
.
The
purpose
of
this
study
is
to
determine
the
utility
of
FDG-PET
/
CT
in
the
clinical
staging
of
early
-
stage
esophageal
cancer
.
Subjects
in
this
retrospective
study
were
79
consecutive
patients
with
cTisN
0
(
high
-grade
dysplasia
)
and
cT
1
N
0
primary
esophageal
adenocarcinoma
diagnosed
by
endoscopy
and
endoscopic
ultrasound
biopsy
that
were
evaluated
with
preoperative
FDG-PET
/
CT
and
had
not
received
neoadjuvant
therapy
.
Seventh
edition
American
Joint
Committee
on
Cancer
cTNM
and
FDG-PET
/
CT
were
compared
with
postoperative
pTNM
staging
.
pT
1
was
subdivided
into
intramucosal
cancers
with
lamina
propria
or
muscularis
mucosa
invasion
(
pT
1
a
)
and
submucosal
cancers
(
pT
1
b
)
.
In
pT
staging
,
the
frequency
of
FDG
uptake
increased
with
increasing
pT
,
from
pT
1
a
21
of
39
(
53
.
8
%
)
to
pT
1
b
19
of
22
(
55
.
8
%
)
.
pTis
was
three
of
five
(
60
.
0
%
)
.
Similarly
,
the
maximum
standardized
uptake
value
of
FDG-avid
lesions
increased
with
increasing
pT
,
with
median
values
of
3
.
7
for
pTis
,
3
.
8
for
pT
1
a
and
4
.
2
for
T
1
b
.
In
cN
staging
,
FDG-PET
/
CT
was
negative
in
76
patients
and
positive
in
three
patients
.
All
three
patients
with
FDG-avid
nodes
on
FDG-PET
/
CT
were
negative
for
metastatic
disease
on
biopsy
.
In
12
patients
with
pN
1
and
in
one
patient
with
N
2
,
FDG-PET
/
CT
was
falsely
negative
.
Sensitivity
and
positive
predictive
value
for
pN
disease
were
0
%
and
accuracy
was
82
%
.
There
were
no
distant
metastases
.
In
cM
staging
,
FDG-PET
/
CT
was
falsely
positive
in
five
patients
(
FDG
avid
nodules
n
=
3
,
distant
nodal
metastasis
n
=
2
)
and
resulted
in
unwarranted
biopsy
in
four
patients
.
F
DG-PET
/
CT
is
not
useful
in
the
TNM
staging
of
primary
adenocarcinoma
of
the
esophagus
when
endoscopy
and
biopsy
indicate
cTis
and
cT
1
.
In
fact
,
FDGPET
/
CT
can
be
detrimental
to
patient
management
.
Because
regional
nodal
metastases
are
uncommon
and
distant
metastases
rare
,
and
as
FDG-PET
/
CT
can
result
in
inappropriate
clinical
care
,
FDG-PET
/
CT
should
not
be
performed
in
the
evaluation
of
early
-
stage
esophageal
cancer
.
Diseases
Validation
Diseases presenting
"is useful in initial staging of locally advanced cancer and after neoadjuvant therapy"
symptom
esophageal adenocarcinoma
esophageal carcinoma
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom