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Long noncoding RNA HOTAIR as an independent prognostic marker in cancer: a meta-analysis.
[esophageal carcinoma]
HOTAIR
,
a
newly
discovered
long
intergenic
noncoding
RNA
(
lincRNA
)
,
has
been
reported
to
be
aberrantly
expressed
in
many
types
of
cancers
.
This
meta
-analysis
summarizes
its
potential
role
as
a
biomarker
in
malignancy
.
A
quantitative
meta
-analysis
was
performed
through
a
systematic
search
in
Pubmed
,
Medline
and
Web
of
Science
for
eligible
papers
on
the
prognostic
impact
of
HOTAIR
in
cancer
from
inception
to
Feb
.
28
,
2014
.
Pooled
hazard
ratios
(
HRs
)
with
95
%
confidence
interval
(
95
%
CI
)
were
calculated
to
summarize
the
effect
.
Nineteen
studies
were
included
in
the
study
,
with
a
total
of
2033
patients
.
A
significant
association
was
observed
between
high
HOTAIR
expression
and
poor
overall
survival
(
OS
)
in
patients
with
cancer
(
pooled
HR
2
.
22
,
95
%
CI
:
1
.
68
-
2
.
93
)
.
Place
of
residence
(
Asian
or
Western
countries
)
,
type
of
cancer
(
digestive
or
non-digestive
disease
)
,
sample
size
(
more
or
less
than
100
)
,
and
paper
quality
(
score
more
or
less
than
85
%
)
did
not
alter
the
significant
predictive
value
of
HOTAIR
in
OS
from
various
kinds
of
cancer
but
preoperative
status
did
.
By
combining
HRs
from
Cox
multivariate
analyses
,
we
found
that
HOTAIR
expression
was
an
independent
prognostic
factor
for
cancer
patients
(
pooled
HR
2
.
26
,
95
%
CI
:
1
.
62
-
3
.
15
)
.
Subgroup
analysis
showed
that
HOTAIR
abundance
was
an
independent
prognostic
factor
for
cancer
metastasis
(
HR
3
.
90
,
95
%
CI
:
2
.
25
-
6
.
74
)
.
For
esophageal
carcinoma
,
high
HOTAIR
expression
was
significantly
associated
with
TNM
stage
(
III
/
IV
vs
.
I
/
II
:
OR
6
.
90
,
95
%
CI
:
2
.
81
-
16
.
9
)
without
heterogeneity
.
In
gastric
cancer
,
HOTAIR
expression
was
found
to
be
significantly
associated
with
lymph
node
metastases
(
present
vs
.
absent
:
OR
4
.
47
,
95
%
CI
:
1
.
88
-
10
.
63
)
and
vessel
invasion
(
positive
vs
.
negative
:
OR
2
.
88
,
95
%
CI
:
1
.
38
-
6
.
04
)
without
obvious
heterogeneity
.
HOTAIR
abundance
may
serve
as
a
novel
predictive
factor
for
poor
prognosis
in
different
types
of
cancers
in
both
Asian
and
Western
countries
.
Diseases
Validation
Diseases presenting
"high hotair expression was significantly associated with tnm stage"
symptom
esophageal carcinoma
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