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Clinical features, outcomes and treatment-related pneumonitis in elderly patients with esophageal carcinoma.
[esophageal carcinoma]
To
investigate
the
clinical
features
and
prognoses
of
elderly
patients
with
esophageal
carcinoma
and
to
compare
the
effects
of
radiotherapy
and
rates
of
treatment-related
pneumonitis
(
TRP
)
between
elderly
and
non-elderly
patients
.
A
total
of
236
patients
with
esophageal
carcinoma
who
received
radiotherapy
between
2002
and
2012
were
enrolled
.
The
patients
were
divided
into
two
groups
:
an
elderly
group
(
age
≥
65
years
)
and
a
non-elderly
group
(
age
<
65
years
)
.
The
tumor
position
and
stage
,
lymph
node
and
distant
metastases
,
and
incidence
and
severity
of
TRP
were
compared
.
Multivariate
analysis
was
applied
to
identify
independent
prognostic
factors
.
The
median
overall
survival
times
after
radiotherapy
in
the
elderly
and
non-elderly
groups
were
18
.
5
and
20
.
5
mo
,
respectively
.
Cox
regression
analysis
showed
that
TRP
grade
and
tumor
-node-metastasis
(
TNM
)
stage
were
independent
prognostic
factors
in
the
elderly
group
.
High
-dose
radiotherapy
(
>
60
Gy
)
was
associated
with
a
high
incidence
of
TRP
.
Tumor
TNM
staging
was
significantly
different
between
the
two
groups
in
which
TRP
occurred
.
Multivariate
analysis
showed
that
TNM
stage
was
an
independent
prognostic
factor
.
Esophageal
carcinoma
in
elderly
patients
was
relatively
less
malignant
compared
with
that
in
non-elderly
patients
.
An
appropriate
dose
should
be
used
to
decrease
the
incidence
of
TRP
in
radiotherapy
,
and
intensity
modulated
radiation
therapy
should
be
selected
if
possible
.
Diseases
Validation
Diseases presenting
"independent prognostic factors"
symptom
carcinoma of the gallbladder
cholangiocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
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