Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Pharmacological Intervention through Dietary Nutraceuticals in Gastrointestinal Neoplasia.
[esophageal carcinoma]
Abstract
Neoplastic
conditions
associated
with
gastrointestinal
(
GI
)
tract
are
common
worldwide
with
colorectal
cancer
alone
accounting
for
the
third
leading
rate
of
cancer
incidence
.
Other
GI
malignancies
such
as
esophageal
carcinoma
have
shown
an
increasing
trend
in
the
last
few
years
.
The
poor
survival
statistics
of
these
fatal
cancer
diseases
highlight
the
need
for
multiple
alternative
treatment
options
along
with
effective
prophylactic
strategies
.
Worldwide
geographical
variation
in
cancer
incidence
indicates
a
correlation
between
dietary
habits
and
cancer
risk
.
Epidemiological
studies
have
suggested
that
populations
with
high
intake
of
certain
dietary
agents
in
their
regular
meals
have
lower
cancer
rates
.
Thus
an
impressive
embodiment
of
evidence
supports
the
concept
that
dietary
factors
are
key
modulators
of
cancer
including
those
of
GI
origin
.
Preclinical
studies
on
animal
models
of
carcinogenesis
have
reflected
the
pharmacological
significance
of
certain
dietary
agents
called
as
nutraceuticals
in
the
chemoprevention
of
GI
neoplasia
.
These
include
stilbenes
(
from
red
grapes
and
red
wine
)
,
isoflavones
(
from
soy
)
,
carotenoids
(
from
tomatoes
)
,
curcuminoids
(
from
spice
turmeric
)
,
catechins
(
from
green
tea
)
and
various
other
small
plant
metabolites
(
from
fruits
,
vegetables
and
cereals
)
.
Pleiotropic
action
mechanisms
have
been
reported
for
these
diet-derived
chemopreventive
agents
to
retard
,
block
or
reverse
carcinogenesis
.
This
review
presents
a
prophylactic
approach
to
primary
prevention
of
GI
cancers
by
highlighting
the
translational
potential
of
plant-derived
nutraceuticals
from
epidemiological
,
laboratory
and
clinical
studies
,
for
the
better
management
of
these
cancers
through
consumption
of
nutraceutical
rich
diets
and
their
intervention
in
cancer
therapeutics
.
Diseases
Validation
Diseases presenting
"esophageal carcinoma"
symptom
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
This symptom has already been validated