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Combined chemotherapy and surgery in primary small cell carcinoma of the esophagus.
[esophageal carcinoma]
The
study
was
to
retrospectively
analyze
survival
outcomes
of
surgery
combined
with
chemotherapy
in
primary
small
cell
carcinoma
of
esophagus
.
From
January
2000
to
December
2009
,
all
patients
with
esophageal
carcinoma
and
underwent
esophagectomy
were
selected
from
the
Department
of
Thoracic
Surgery
,
Henan
Cancer
Hospital
,
China
.
They
were
performed
trans--left
thoracic
incision
esophagectomy
.
For
tumor
located
in
the
upper
third
thoracic
esophagus
,
trans--
right
thoracic
incision
and
abdomen
incision
esophagectomy
was
selected
.
We
chose
EP
regimen
for
chemotherapy
.
Results
:
The
percentage
of
pure
esophagus
small
cell
carcinoma
(
57
cases
)
in
all
patients
underwent
esophagectomy
was
1
.
1
%
.
The
median
survival
time
was
45
months
.
In
stage
I
,
II
,
III
,
the
survival
rate
was
25
%
,
5
.
9
%
,
4
.
3
%
respectively
.
In
the
subgroup
analysis
,
overall
median
survival
time
of
surgery
was
23
.
2
months
while
the
time
of
combined
surgery
and
chemotherapy
was
60
.
7
months
(
P
<
0
.
01
)
.
For
stage
I
patients
,
combined
therapy
was
associated
with
a
significant
longer
median
survival
time
(
81
.
9
months
)
than
surgery
alone
(
22
.
3
months
)
.
(
P
<
0
.
01
)
.
Systemic
chemotherapy
of
cisplatin--based
regimens
should
be
considered
as
important
treatment
options
to
improve
survival
outcome
,
even
early
small
cell
esophageal
cancer
.
Diseases
Validation
Diseases presenting
"overall median survival time"
symptom
esophageal carcinoma
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