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Association of Kruppel-like factor 4 expression with the prognosis of esophageal squamous cell carcinoma patients.
[esophageal carcinoma]
To
investigate
the
association
of
Kruppel-like
factor
4
(
KLF
4
)
expressions
with
the
prognosis
of
esophageal
squamous
cell
carcinoma
(
SCC
)
patients
.
Ninety
-
eight
cases
of
esophageal
carcinoma
patients
were
enrolled
.
The
expression
of
KLF
4
in
the
esophageal
SCC
and
normal
esophageal
mucosa
tissues
were
examined
by
immunohistochemistry
.
The
correlations
between
the
expression
of
KLF
4
protein
and
patients
'
clinical
characteristics
and
prognosis
were
analyzed
.
We
observed
higher
expressed
KLF
4
in
normal
esophageal
mucosa
tissues
than
esophageal
SCC
tissues
,
with
positive
rate
of
82
.
7
%
(
81
/
98
)
and
43
.
8
%
(
43
/
98
)
respectively
.
In
patients
with
lymphatic
metastasis
,
the
positive
rate
of
KLF
4
was
24
.
4
%
(
10
/
41
)
,
whereas
it
was
57
.
9
%
(
33
/
57
)
in
patients
without
lymphatic
metastasis
,
and
the
difference
was
significant
(
x
(
2
)
=
10
.
871
,
P
=
0
.
001
)
.
The
positive
rates
of
KLF
4
were
62
.
5
%
(
5
/
8
)
,
53
.
1
%
(
26
/
49
)
and
29
.
3
%
(
12
/
41
)
in
stage
I
,
II
and
III
patients
,
respectively
.
There
were
no
correlations
between
the
expression
of
KLF
4
and
gender
,
age
,
tumor
size
,
location
,
differentiation
grade
and
infiltration
depth
.
The
5
-
year
survival
rates
and
median
survival
times
were
48
.
8
%
and
25
.
5
%
,
and
55
and
26
months
for
the
patients
with
KLF
4
positive
and
negative
expression
,
respectively
.
There
were
significant
differences
between
the
patients
with
KLF
4
positive
expression
and
negative
expression
in
the
5
-
year
survival
rates
and
median
survival
times
(
x
(
2
)
=
5
.
747
and
4
.
493
,
P
=
0
.
017
and
0
.
034
)
.
KLF
4
might
act
as
a
tumor
suppressor
in
esophageal
SCC
and
the
expression
status
of
KLF
4
could
be
considered
as
a
prognosis
predictor
for
esophageal
SCC
patients
.
Diseases
Validation
Diseases presenting
"positive rate"
symptom
achondroplasia
alpha-thalassemia
congenital adrenal hyperplasia
esophageal carcinoma
esophageal squamous cell carcinoma
familial mediterranean fever
heparin-induced thrombocytopenia
homocystinuria without methylmalonic aciduria
scrub typhus
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