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A random Abstract
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Association of Kruppel-like factor 4 expression with the prognosis of esophageal squamous cell carcinoma patients.
[esophageal carcinoma]
To
investigate
the
association
of
Kruppel-like
factor
4
(
KLF
4
)
expressions
with
the
prognosis
of
esophageal
squamous
cell
carcinoma
(
SCC
)
patients
.
Ninety
-
eight
cases
of
esophageal
carcinoma
patients
were
enrolled
.
The
expression
of
KLF
4
in
the
esophageal
SCC
and
normal
esophageal
mucosa
tissues
were
examined
by
immunohistochemistry
.
The
correlations
between
the
expression
of
KLF
4
protein
and
patients
'
clinical
characteristics
and
prognosis
were
analyzed
.
We
observed
higher
expressed
KLF
4
in
normal
esophageal
mucosa
tissues
than
esophageal
SCC
tissues
,
with
positive
rate
of
82
.
7
%
(
81
/
98
)
and
43
.
8
%
(
43
/
98
)
respectively
.
In
patients
with
lymphatic
metastasis
,
the
positive
rate
of
KLF
4
was
24
.
4
%
(
10
/
41
)
,
whereas
it
was
57
.
9
%
(
33
/
57
)
in
patients
without
lymphatic
metastasis
,
and
the
difference
was
significant
(
x
(
2
)
=
10
.
871
,
P
=
0
.
001
)
.
The
positive
rates
of
KLF
4
were
62
.
5
%
(
5
/
8
)
,
53
.
1
%
(
26
/
49
)
and
29
.
3
%
(
12
/
41
)
in
stage
I
,
II
and
III
patients
,
respectively
.
There
were
no
correlations
between
the
expression
of
KLF
4
and
gender
,
age
,
tumor
size
,
location
,
differentiation
grade
and
infiltration
depth
.
The
5
-
year
survival
rates
and
median
survival
times
were
48
.
8
%
and
25
.
5
%
,
and
55
and
26
months
for
the
patients
with
KLF
4
positive
and
negative
expression
,
respectively
.
There
were
significant
differences
between
the
patients
with
KLF
4
positive
expression
and
negative
expression
in
the
5
-
year
survival
rates
and
median
survival
times
(
x
(
2
)
=
5
.
747
and
4
.
493
,
P
=
0
.
017
and
0
.
034
)
.
KLF
4
might
act
as
a
tumor
suppressor
in
esophageal
SCC
and
the
expression
status
of
KLF
4
could
be
considered
as
a
prognosis
predictor
for
esophageal
SCC
patients
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated