Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis.
[esophageal carcinoma]
Objective
.
Recently
,
many
studies
have
shown
that
microRNAs
(
miRNA
)
exhibit
altered
expression
in
various
cancers
and
may
play
an
important
role
as
prognostic
biomarker
of
cancers
.
We
performed
a
meta
-analysis
to
evaluate
the
impact
of
miR-
375
expression
in
solid
tumors
on
patients
'
overall
survival
(
OS
)
.
Methods
.
Studies
were
identified
by
searching
PubMed
,
Embace
,
and
Cochrane
Library
(
last
search
update
was
in
May
2014
)
and
were
assessed
by
further
quality
evaluation
.
The
pooled
hazard
ratios
(
HRs
)
with
95
%
confidence
intervals
(
CIs
)
for
total
and
stratified
analyses
were
calculated
to
investigate
the
association
between
miR-
375
expression
and
cancer
patients
OS
.
Results
.
Our
analysis
results
indicated
that
downregulation
of
miR-
375
predicted
poor
OS
(
HR
=
1
.
91
,
95
%
CI
1
.
48
-
2
.
45
,
P
<
0
.
001
)
.
Subgroup
analyses
showed
that
lower
expression
of
miR-
375
was
significantly
related
with
poor
OS
in
patients
with
esophageal
carcinoma
(
HR
=
2
.
24
,
95
%
CI
1
.
69
-
2
.
96
,
P
<
0
.
001
)
and
non-
small
-cell
lung
cancer
(
NSCLC
)
(
HR
=
1
.
71
,
95
%
CI
1
.
31
-
2
.
24
,
P
<
0
.
001
)
.
Conclusions
.
The
findings
from
this
meta
-analysis
suggest
that
miR-
375
expression
is
associated
with
OS
of
patients
with
malignant
tumors
and
could
be
a
useful
clinical
prognostic
biomarker
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated