Overexpression of interleukin-8 receptor 2 (IL-8R2) indicates better prognosis in esophageal adenocarcinoma and squamous cell carcinoma procession.

[esophageal adenocarcinoma]

Researches have showed that interleukin family or receptors play a role in many human tumor progressions including esophageal carcinoma . In this study , we examined the expression of interleukin-8 receptor 2 (IL -8 R 2 ) and analyze the relationship between it and esophageal carcinoma clinical characteristics . IL -8 R 2 protein expression was confirmed by immunohistochemistry and immunofluorescence arrays and was analyzed further via Western blot and qRT-PCR analysis in frozen tissues . The correlation between their expression levels and clinical characteristics were evaluated by Mann-Whitney and Kruskal-Wallis test . Via Kaplan-Meier plots and Cox proportional hazard models , overall survival (OS ) was analyzed . Compared with normal esophageal tissue , IL -8 R 2 protein was overexpressed significantly in esophageal cancer (p < 0 .05 ) and was observed both in cytoplasm and nuclear . The lower expression of IL -8 R 2 protein was observed with higher p staging of esophageal cancer , and the significant association between them was confirmed (p = 0 .000 ), and in advanced p T stage , the similar result was obtained (p = 0 .015 ); however , compared with lymph node metastasis-negative group , it is no significant difference in positive group (p = 0 .152 ). In a Kaplan-Meier analysis , compared with IL -8 R 2 low expression , IL -8 R 2 high expression identified a group of patients with the longest OS . Cox proportional hazard models revealed that IL -8 R 2 predicted long time to OS . The higher expression of IL -8 R 2 was found in early esophageal carcinoma , which may indicate that IL -8 R 2 plays an important role and is better prognostic factor in esophageal cancer development .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated