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Chemoprevention of esophageal adenocarcinoma in a rat model by ursodeoxycholic acid.
[esophageal adenocarcinoma]
Reflux
of
bile
acid
into
the
esophagus
induces
esophagitis
,
inflammation
-stimulated
hyperplasia
,
metaplasia
such
as
Barrett
's
esophagus
(
BE
)
,
and
esophageal
adenocarcinoma
(
EAC
)
.
Caudal-
type
homeobox
2
(
Cdx
2
)
via
nuclear
factor
(
NF
)
-
κB
induced
by
bile
acid
is
an
important
factor
in
the
development
of
BE
and
EAC
.
In
colorectal
cancer
,
experimental
data
suggest
a
chemopreventive
effect
of
ursodeoxycholic
acid
(
UDCA
)
.
We
hypothesized
that
UDCA
may
protect
against
the
esophageal
inflammation
-metaplasia-carcinoma
sequence
by
decreasing
the
overall
proportion
of
the
toxic
bile
acids
.
Wistar
male
rats
that
underwent
a
duodenoesophageal
reflux
procedure
were
divided
into
two
groups
.
One
group
was
given
commercial
chow
(
control
group
)
,
and
the
other
was
given
experimental
chow
containing
UDCA
(
UDCA
group
)
.
The
animals
were
killed
at
40
weeks
after
surgery
,
and
their
bile
and
esophagus
were
examined
.
In
the
UDCA
group
,
the
esophagitis
was
milder
and
the
incidence
of
BE
was
significantly
lower
(
p
<
0
.
05
)
than
in
the
control
group
,
and
EAC
was
not
observed
(
p
<
0
.
05
)
.
In
analysis
of
the
compartment
of
bile
acid
,
UDCA
was
markedly
increased
in
the
UDCA
group
compared
with
the
control
group
(
32
.
7
±
11
.
4
vs
.
0
.
82
±
0
.
33
mmol
/
L
,
p
<
0
.
05
)
and
cholic
acid
was
decreased
(
32
.
7
±
4
.
05
vs
.
60
.
9
±
8
.
26
mmol
/
L
,
p
<
0
.
05
)
.
Expression
intensity
of
Cdx
2
and
NF-κB
was
greater
in
the
control
group
than
in
the
UDCA
group
(
p
<
0
.
05
)
.
UDCA
may
be
a
chemopreventive
agent
against
EAC
by
varying
the
bile
acid
composition
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
