Cytochrome P450 1A1 (CYP1A1) polymorphism and susceptibility to esophageal cancer: an updated meta-analysis of 27 studies.

[esophageal adenocarcinoma]

Cytochrome P 450 1 A 1 (CYP 1 A 1 ) polymorphisms are known to play a crucial role in the development and metastasis of malignant diseases including esophageal cancer . However , the results of previous studies investigating the association between CYP 1 A 1 polymorphisms and esophageal cancer risk have been inconsistent . This meta -analysis of 27 eligible studies , encompassing 4 ,215 esophageal cancer cases and 6 ,339 control subjects , pooled the odds ratios (ORs ) with corresponding 95 % confidence intervals (95 % CI ) to assess this association . The effects of ethnicity (Caucasian and Asian ) and histopathology type (esophageal squamous cell carcinoma and esophageal adenocarcinoma ) were considered in subgroup analyses . A significant association was observed between the CYP 1 A 1 Ile /Val gene polymorphism and esophageal cancer in all of the genetic models (Ile /Val vs . Ile /Ile , OR = 1 .41 , 95 % CI = 1 .25 -1 .58 ; Val /Val vs . Ile /Ile , OR = 1 .94 , 95 % CI = 1 .34 -2 .82 ; Ile /Val + Val /Val vs . Ile /Ile , OR = 1 .49 , 95 % CI = 1 .33 -1 .66 ). The subgroup analysis based on ethnicity showed that the association between the CYP 1 A 1 Ile /Val polymorphism and esophageal cancer existed in Asian and Caucasian populations . However , no association was observed between the CYP 1 A 1 MspI polymorphism and esophageal cancer in either subgroup or in the overall population . These results suggested that the CYP 1 A 1 Ile /Val polymorphism was associated with an increased risk of esophageal cancer , whereas the CYP 1 A 1 MspI polymorphism may not have increased susceptibility to esophageal cancer . Further studies are required to confirm these findings .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated