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Cytochrome P450 1A1 (CYP1A1) polymorphism and susceptibility to esophageal cancer: an updated meta-analysis of 27 studies.
[esophageal adenocarcinoma]
Cytochrome
P
450
1
A
1
(
CYP
1
A
1
)
polymorphisms
are
known
to
play
a
crucial
role
in
the
development
and
metastasis
of
malignant
diseases
including
esophageal
cancer
.
However
,
the
results
of
previous
studies
investigating
the
association
between
CYP
1
A
1
polymorphisms
and
esophageal
cancer
risk
have
been
inconsistent
.
This
meta
-analysis
of
27
eligible
studies
,
encompassing
4
,
215
esophageal
cancer
cases
and
6
,
339
control
subjects
,
pooled
the
odds
ratios
(
ORs
)
with
corresponding
95
%
confidence
intervals
(
95
%
CI
)
to
assess
this
association
.
The
effects
of
ethnicity
(
Caucasian
and
Asian
)
and
histopathology
type
(
esophageal
squamous
cell
carcinoma
and
esophageal
adenocarcinoma
)
were
considered
in
subgroup
analyses
.
A
significant
association
was
observed
between
the
CYP
1
A
1
Ile
/
Val
gene
polymorphism
and
esophageal
cancer
in
all
of
the
genetic
models
(
Ile
/
Val
vs
.
Ile
/
Ile
,
OR
=
1
.
41
,
95
%
CI
=
1
.
25
-
1
.
58
;
Val
/
Val
vs
.
Ile
/
Ile
,
OR
=
1
.
94
,
95
%
CI
=
1
.
34
-
2
.
82
;
Ile
/
Val
+
Val
/
Val
vs
.
Ile
/
Ile
,
OR
=
1
.
49
,
95
%
CI
=
1
.
33
-
1
.
66
)
.
The
subgroup
analysis
based
on
ethnicity
showed
that
the
association
between
the
CYP
1
A
1
Ile
/
Val
polymorphism
and
esophageal
cancer
existed
in
Asian
and
Caucasian
populations
.
However
,
no
association
was
observed
between
the
CYP
1
A
1
MspI
polymorphism
and
esophageal
cancer
in
either
subgroup
or
in
the
overall
population
.
These
results
suggested
that
the
CYP
1
A
1
Ile
/
Val
polymorphism
was
associated
with
an
increased
risk
of
esophageal
cancer
,
whereas
the
CYP
1
A
1
MspI
polymorphism
may
not
have
increased
susceptibility
to
esophageal
cancer
.
Further
studies
are
required
to
confirm
these
findings
.
Diseases
Validation
Diseases presenting
"in the overall population"
symptom
esophageal adenocarcinoma
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