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Usefulness of insulin-like growth factor II mRNA-binding protein 3 (IMP3) as a new marker for the diagnosis of esophageal adenocarcinoma in challenging cases.
[esophageal adenocarcinoma]
Insulin
-like
growth
factor
II
mRNA-binding
protein
3
(
IMP
3
)
is
an
oncofetal
protein
with
vital
function
during
human
embryogenesis
in
terms
of
cellular
growth
and
migration
.
Although
it
has
minimum
and
undetectable
expression
in
human
adult
tissues
,
it
is
highly
expressed
in
various
types
of
cancer
.
Few
studies
have
recommend
application
of
IMP
3
expression
to
diagnose
challenging
cases
of
esophageal
adenocarcinoma
.
This
survey
was
aimed
to
evaluate
the
benefit
of
IMP
3
expression
detection
in
the
diagnosis
of
esophageal
adenocarcinoma
and
high
-grade
dysplasia
by
using
immunohistochemistry
(
IHC
)
.
An
immunohistochemistry
study
of
IMP
3
oncofetal
protein
was
performed
on
paraffin-embedded
blocks
of
76
cases
,
including
Barrett
's
esophagus
,
esophageal
squamous
epithelium
,
Barrett
's
esophagus
with
low
-grade
dysplasia
,
Barrett
's
esophagus
with
high
-grade
dysplasia
,
moderately
differentiated
esophageal
adenocarcinoma
,
and
poorly
differentiated
esophageal
adenocarcinoma
.
Two
pathologists
reevaluated
the
diagnosis
and
evaluated
the
positivity
and
intensity
of
the
IHC
staining
as
well
.
I
nsulin
-like
growth
factor
II
mRNA-binding
protein
3
expression
was
intensely
positive
in
all
cases
of
esophageal
adenocarcinoma
and
Barrett
's
esophagus
with
HGD
.
Only
mild
positivity
in
30
%
of
Barrett
's
esophagus
with
LGD
was
seen
.
However
,
Barrett
's
esophagus
and
esophageal
squamous
epithelium
had
,
in
fact
,
no
IMP
3
expression
.
The
percentage
and
intensity
of
IP
3
IHC
staining
showed
a
significant
difference
between
high
-grade
dysplasia
and
adenocarcinoma
versus
Barrett
's
esophagus
with
low
-grade
dysplasia
,
Barrett
's
esophagus
,
and
esophageal
squamous
epithelium
.
Therefore
,
IMP
3
oncofetal
protein
could
be
a
very
useful
marker
for
the
diagnosis
of
high
-grade
dysplasia
and
adenocarcinoma
.
However
,
to
test
the
validation
,
a
larger
number
samples
is
required
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated