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Epidermal growth factor receptor (EGFR) is an independent adverse prognostic factor in esophageal adenocarcinoma patients treated with cisplatin-based neoadjuvant chemotherapy.
[esophageal adenocarcinoma]
Neoadjuvant
platin-based
therapy
is
accepted
as
a
standard
therapy
for
advanced
esophageal
adenocarcinoma
(
EAC
)
.
Patients
who
respond
have
a
better
survival
prognosis
,
but
still
a
significant
number
of
responder
patients
die
from
tumor
recurrence
.
Molecular
markers
for
prognosis
in
neoadjuvantly
treated
EAC
patients
have
not
been
identified
yet
.
We
investigated
the
epidermal
growth
factor
receptor
(
EGFR
)
in
prognosis
and
chemotherapy
resistance
in
these
patients
.
Two
EAC
patient
cohorts
,
either
treated
by
neoadjuvant
cisplatin-based
chemotherapy
followed
by
surgery
(
n
=
86
)
or
by
surgical
resection
(
n
=
46
)
were
analyzed
for
EGFR
protein
expression
and
gene
copy
number
.
Data
were
correlated
with
clinical
and
histopathological
response
,
disease-free
and
overall
survival
.
In
case
of
EGFR
overexpression
,
the
prognosis
for
neoadjuvant
chemotherapy
responders
was
poor
as
in
non-responders
.
Responders
had
a
significantly
better
disease-free
survival
than
non-responders
only
if
EGFR
expression
level
(
p
=
0
.
0152
)
or
copy
number
(
p
=
0
.
0050
)
was
low
.
Comparing
neoadjuvantly
treated
patients
and
primary
resection
patients
,
tumors
of
non-responder
patients
more
frequently
exhibited
EGFR
overexpression
,
providing
evidence
that
EGFR
is
a
factor
for
indicating
chemotherapy
resistance
.
EGFR
overexpression
and
gene
copy
number
are
independent
adverse
prognostic
factors
for
neoadjuvant
chemotherapy-treated
EAC
patients
,
particularly
for
responders
.
Furthermore
,
EGFR
overexpression
is
involved
in
resistance
to
cisplatin-based
neoadjuvant
chemotherapy
.
Diseases
Validation
Diseases presenting
"tumor recurrence"
symptom
carcinoma of the gallbladder
cholangiocarcinoma
cutaneous mastocytosis
dedifferentiated liposarcoma
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
liposarcoma
pleomorphic liposarcoma
thoracic outlet syndrome
von hippel-lindau disease
well-differentiated liposarcoma
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