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Epidermal growth factor receptor (EGFR) is an independent adverse prognostic factor in esophageal adenocarcinoma patients treated with cisplatin-based neoadjuvant chemotherapy.
[esophageal adenocarcinoma]
Neoadjuvant
platin-based
therapy
is
accepted
as
a
standard
therapy
for
advanced
esophageal
adenocarcinoma
(
EAC
)
.
Patients
who
respond
have
a
better
survival
prognosis
,
but
still
a
significant
number
of
responder
patients
die
from
tumor
recurrence
.
Molecular
markers
for
prognosis
in
neoadjuvantly
treated
EAC
patients
have
not
been
identified
yet
.
We
investigated
the
epidermal
growth
factor
receptor
(
EGFR
)
in
prognosis
and
chemotherapy
resistance
in
these
patients
.
Two
EAC
patient
cohorts
,
either
treated
by
neoadjuvant
cisplatin-based
chemotherapy
followed
by
surgery
(
n
=
86
)
or
by
surgical
resection
(
n
=
46
)
were
analyzed
for
EGFR
protein
expression
and
gene
copy
number
.
Data
were
correlated
with
clinical
and
histopathological
response
,
disease-free
and
overall
survival
.
In
case
of
EGFR
overexpression
,
the
prognosis
for
neoadjuvant
chemotherapy
responders
was
poor
as
in
non-responders
.
Responders
had
a
significantly
better
disease-free
survival
than
non-responders
only
if
EGFR
expression
level
(
p
=
0
.
0152
)
or
copy
number
(
p
=
0
.
0050
)
was
low
.
Comparing
neoadjuvantly
treated
patients
and
primary
resection
patients
,
tumors
of
non-responder
patients
more
frequently
exhibited
EGFR
overexpression
,
providing
evidence
that
EGFR
is
a
factor
for
indicating
chemotherapy
resistance
.
EGFR
overexpression
and
gene
copy
number
are
independent
adverse
prognostic
factors
for
neoadjuvant
chemotherapy-treated
EAC
patients
,
particularly
for
responders
.
Furthermore
,
EGFR
overexpression
is
involved
in
resistance
to
cisplatin-based
neoadjuvant
chemotherapy
.
Diseases
Validation
Diseases presenting
"advanced esophageal adenocarcinoma"
symptom
esophageal adenocarcinoma
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