Body Mass Index and Risk of Second Obesity-Associated Cancers After Colorectal Cancer: A Pooled Analysis of Prospective Cohort Studies.

[esophageal adenocarcinoma]

To determine whether prediagnostic body mass index (BMI ) is associated with risk of second obesity -associated cancers in colorectal cancer (CRC ) survivors , and whether CRC survivors have increased susceptibility to obesity -associated cancer compared with cancer -free individuals .Incident first primary CRC cases (N = 11 ,598 ) were identified from five prospective cohort studies . We used Cox proportional hazards regression models to examine associations between baseline (prediagnostic ) BMI and risk of second obesity -associated cancers (postmenopausal breast , kidney , pancreas , esophageal adenocarcinoma , endometrium ) in CRC survivors , and compared associations to those for first obesity -associated cancers in the full cohort .Compared with survivors with normal prediagnostic BMI (18 .5 -24 .9 kg /m (2 )), those who were overweight (25 -29 .9 kg /m (2 )) or obese (30 + kg /m (2 )) had greater risk of a second obesity -associated cancer (n = 224 ; overweight hazard ratio [HR ], 1 .39 ; 95 % CI , 1 .01 to 1 .92 ; obese HR , 1 .47 ; 95 % CI , 1 .02 to 2 .12 ; per 5 -unit change in BMI HR , 1 .12 ; 95 % CI , 0 .98 to 1 .29 ). The magnitude of risk for developing a first primary obesity -associated cancer was similar (overweight HR , 1 .18 ; 95 % CI , 1 .14 to 1 .21 ; obese HR , 1 .61 ; 95 % CI , 1 .56 to 1 .66 ; per 5 -unit change in BMI HR , 1 .23 ; 95 % CI , 1 .21 to 1 .24 ). Before diagnosis CRC patients were somewhat more likely than the overall cohort to be overweight (44 % v 41 %) or obese (25 % v 21 %).CRC survivors who were overweight or obese before diagnosis had increased risk of second obesity -associated cancers compared with survivors with normal weight . The risks were similar in magnitude to those observed for first cancers in this population , suggesting increased prevalence of overweight or obesity , rather than increased susceptibility , may contribute to elevated second cancer risks in colorectal cancer survivors compared with the general population . These results support emphasis of existing weight guidelines for this high -risk group .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated