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A random Abstract
Our Project
Our Team
Prognostic classification of histopathologic response to neoadjuvant therapy in esophageal adenocarcinoma.
[esophageal adenocarcinoma]
To
evaluate
the
histopathologic
response
to
neoadjuvant
therapy
in
esophageal
adenocarcinoma
according
to
impact
on
prognosis
and
to
suggest
a
classification
for
clinical
routine
.
Measures
of
histopathologic
response
to
neoadjuvant
treatment
of
esophageal
cancer
such
as
Mandard
tumor
regression
grading
focus
on
the
effect
on
the
primary
tumor
.
Although
lymph
node
infiltration
is
of
significant
prognostic
importance
,
this
criterion
is
mostly
not
included
in
the
response
classifications
.
A
total
of
370
patients
(
89
%
males
,
median
age
:
61
years
)
with
neoadjuvant
radiochemotherapy
(
40
Gy
,
5
-
FU
,
cisplatin
)
or
chemotherapy
(
MAGIC
or
FLOT
)
for
cT
3
,
Nx
,
M
0
esophageal
adenocarcinoma
were
included
in
the
analysis
.
All
patients
had
undergone
transthoracic
en
bloc
esophagectomy
,
with
a
median
of
27
resected
lymph
nodes
and
a
R
0
-
resection
rate
of
92
%
.
Histopathologic
regression
grading
differentiated
major
or
minor
response
according
to
less
or
more
than
10
%
vital
cells
in
the
primary
tumor
.
The
lymph
nodes
were
classified
as
ypN
0
or
ypN
+
.
From
the
patients
with
R
0
resection
and
M
0
category
,
3
groups
with
significantly
different
5
-
year
survival
rates
(
5
-
YSR
)
could
be
differentiated
:
:
A
combined
classification
of
primary
tumor
regression
and
lymph
node
status
in
3
grades
represents
a
simple
and
reproducible
prognostic
classification
of
the
effect
of
neoadjuvant
treatment
in
esophageal
adenocarcinoma
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated