Epicardial fat thickness and left ventricular mass in subjects with adrenal incidentaloma.

[adrenal incidentaloma]

Emerging evidences indicate that patients diagnosed with adrenal incidentaloma may present with cardiovascular complications . Epicardial fat is known to play a role in left ventricle (LV ) changes . Whether epicardial fat can be associated with LV mass (LVM ) in patients with incidentaloma is unknown . We test the hypothesis that echocardiographic epicardial fat thickness is independently related to LVM in a well-studied group of subjects with adrenal incidentaloma . 46 consecutive patients (age 59 ± 9 years ) with imaging diagnosis of adrenal incidentaloma and 30 healthy controls underwent echocardiogram for epicardial fat thickness and LVM measurement . Non-functional incidentaloma was confirmed in 40 subjects , whereas 6 patients were actually diagnosed with mild Cushing 's syndrome . Epicardial fat thickness was significantly higher in patients with incidentaloma and mild Cushing 's syndrome when compared to controls , (p < 0 .01 for both ). LVM (h 2 .7 ) was higher in subjects with adrenal incidentaloma than in controls and higher in subjects with mild Cushing 's syndrome than in those with adrenal incidentaloma (p < 0 .05 and p < 0 .01 ). Multiple regression analysis showed that epicardial fat thickness was the best correlate (R (2 ) = 0 .36 , β 2 .8 , p < 0 .01 ) of LVM in overall study patients . We showed for the first time that (1 ) epicardial fat thickness and LVM are higher in subjects with adrenal incidentaloma and (2 ) epicardial fat thickness independently correlates with LVM . Echocardiographic epicardial fat may serve as non-invasive marker of visceral fat and earlier cardiac abnormalities in patients with adrenal incidentaloma .

Diseases
Validation

Diseases presenting "first time" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

adrenomyeloneuropathy

alpha-thalassemia

aniridia

aromatase deficiency

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

classical phenylketonuria

congenital adrenal hyperplasia

congenital toxoplasmosis

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dentin dysplasia

dentinogenesis imperfecta

dracunculiasis

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

fabry disease

familial mediterranean fever

gm1 gangliosidosis

harlequin ichthyosis

heparin-induced thrombocytopenia

hirschsprung disease

hodgkin lymphoma, classical

holt-oram syndrome

hydrocephalus with stenosis of the aqueduct of sylvius

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

malignant atrophic papulosis

megacystis-microcolon-intestinal hypoperistalsis syndrome

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

omenn syndrome

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

phenylketonuria

primary effusion lymphoma

primary hyperoxaluria type 1

severe combined immunodeficiency

sneddon syndrome

triple a syndrome

trochlear dysplasia

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

zellweger syndrome

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