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[Alpha-melanocyte-stimulating hormone. From bench to bedside].
[erythropoietic protoporphyria]
Alpha
-melanocyte-stimulating
hormone
(
alpha-
MSH
)
is
a
tridecapeptide
that
is
produced
by
the
skin
itself
from
the
precursor
proopiomelanocortin
.
It
crucially
mediates
ultraviolet
light-induced
tanning
after
binding
to
melanocortin-
1
receptors
(
MC
-
1
R
)
expressed
on
the
surface
of
epidermal
melanocytes
.
The
potent
pigment-inducing
and
also
cytoprotective
actions
of
alpha-
MSH
are
the
rationale
for
the
performance
of
first
phase
II
clinical
trials
with
Nle
4
-
D-Phe
7
-
alpha-
MSH
(
NDP
-alpha-MSH
)
,
a
subcutaneously
administered
synthetic
and
superpotent
alpha-
MSH
analogue
,
in
patients
with
photodermatoses
such
as
erythropoietic
protoporphyria
.
Since
alpha-
MSH
has
shown
promising
anti-
inflammatory
and
antifibrotic
properties
in
numerous
preclinical
studies
,
it
will
be
most
interesting
to
evaluate
these
effects
in
further
clinical
pilot
studies
with
NDP
-alpha-MSH
.
In
addition
to
alpha-
MSH
analogues
,
truncated
tripeptides
such
as
KDPT
which
do
not
bind
to
MC
-
1
R
but
have
sustained
anti-
inflammatory
properties
are
currently
emerging
as
another
novel
therapeutic
strategy
in
dermatology
.
