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Maternal and fetal outcome in Swedish women with erythropoietic protoporphyria.
[erythropoietic protoporphyria]
Painful
photosensitivity
is
characteristic
of
erythropoietic
protoporphyria
(
EPP
)
.
In
women
,
symptoms
may
be
affected
by
menstrual
cycle
and
pregnancy
but
very
little
is
known
about
maternal
and
fetal
outcome
.
To
investigate
the
impact
of
menstruation
,
pregnancy
and
breast
-feeding
on
photosensitivity
and
possible
effects
of
EPP
on
maternal
,
fetal
and
neonatal
outcome
.
Retrospective
study
screening
all
20
Swedish
women
alive
and
older
than
18
years
diagnosed
with
EPP
with
a
total
of
33
deliveries
.
Data
were
retrieved
for
19
women
and
32
deliveries
in
medical
records
and
completed
by
a
questionnaire
sent
to
the
patients
.
Photosensitivity
worsened
in
five
of
19
(
26
%
)
women
around
menstruation
whereas
amelioration
was
reported
in
17
of
32
(
53
%
)
pregnancies
and
during
11
of
32
(
34
%
)
breast
-feeding
periods
.
Fertility
rate
was
normal
and
there
were
no
maternal
or
fetal
complications
apart
from
minor
arterial
hypertension
in
one
woman
.
The
study
confirms
changes
in
photosensitivity
during
menstruation
and
pregnancy
.
Amelioration
during
breast
-feeding
is
a
new
finding
.
Pregnancy
appears
safe
without
increased
risks
of
pregnancy
complications
or
adverse
effects
on
fetal
or
neonatal
health
.
