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Protective action of antioxidants on hepatic damage induced by griseofulvin.
[erythropoietic protoporphyria]
Erythropoietic
protoporphyria
(
EPP
)
is
a
disease
associated
with
ferrochelatase
deficiency
and
characterized
by
the
accumulation
of
protoporphyrin
IX
(
PROTO
IX
)
in
erythrocytes
,
liver
,
and
skin
.
In
some
cases
,
a
severe
hepatic
failure
and
cholestasis
were
observed
.
Griseofulvin
(
Gris
)
develops
an
experimental
EPP
with
hepatic
manifestations
in
mice
such
as
PROTO
IX
accumulation
followed
by
cellular
damage
as
wells
as
necrotic
and
inflammatory
processes
.
The
antioxidant
defense
system
was
also
altered
.
The
aim
was
to
evaluate
the
possible
protective
effect
of
different
antioxidant
compounds
:
trolox
(
Tx
)
,
ascorbic
acid
(
Asc
)
,
the
combination
Tx
and
Asc
,
melatonin
(
Mel
)
,
and
the
polyphenols
:
ellagic
acid
,
quercetin
,
chlorogenic
acid
,
caffeic
acid
,
gallic
acid
,
and
ferulic
acid
on
liver
damage
and
oxidative
stress
markers
in
a
mouse
model
of
EPP
.
Coadministration
of
Gris
with
Tx
,
Asc
,
and
its
combination
,
or
Mel
mainly
affected
heme
biosynthetic
pathway
,
resulting
in
a
decrease
in
ALA
-S
activity
which
was
increased
by
Gris
,
while
the
tested
polyphenols
exerted
a
protective
effect
on
oxidative
stress
,
decreasing
lipid
peroxidation
and
the
activity
of
some
antioxidant
enzymes
.
In
conclusion
,
antioxidant
compounds
can
only
protect
partially
against
the
liver
damage
induced
by
Gris
,
reducing
oxidative
stress
or
acting
on
heme
regulation
.
Diseases
Validation
Diseases presenting
"severe hepatic failure"
symptom
erythropoietic protoporphyria
heparin-induced thrombocytopenia
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