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Minireview: Peptide analogs and short sequence oligopeptides as modulators of skin pigmentation.
[erythropoietic protoporphyria]
Short
sequence
amino
acids
or
oligopeptides
have
recently
garnered
attention
for
use
as
treatments
for
a
myriad
of
dermatologic
disorders
due
to
their
ability
to
effect
and
modulate
various
biological
processes
in
the
epidermis
and
dermis
,
rendering
them
promising
candidates
as
medical
and
cosmeceutical
therapeutics
.
Major
advantages
include
their
relative
ease
of
synthesis
and
multitude
of
modifications
that
can
be
applied
to
enhance
potency
,
affinity
,
specificity
,
hydrophilicity
or
hydrophobicity
and
cytotoxicity
.
Given
the
photoprotective
effects
of
eumelanin
on
skin
,
there
has
been
substantial
interest
in
developing
agents
,
particularly
α-
MSH
analogs
,
that
can
induce
'
sunless
tanning
'
helping
reduce
risk
of
melanoma
and
non-
melanoma
skin
cancer
.
In
this
mini
review
,
we
present
some
of
the
recent
and
leading
peptide
modulators
of
melanogenesis
with
relevant
clinical
data
and
medical
indications
.
Short
sequence
oligopeptides
with
tyrosinase
inhibitory
activity
that
can
significantly
reduce
hyperpigmentation
,
as
well
α-
MSH
analogs
that
can
enhance
eumelanogenesis
,
are
currently
being
clinically
tested
for
treatment
of
erythropoietic
protoporphyria
,
polymorphous
light
eruption
,
solar
urticaria
,
actinic
keratosis
,
and
"
sunless
tanning
"
.
Success
in
developing
such
products
can
help
reduce
the
incidence
of
skin
cancer
,
one
that
surpasses
that
of
all
other
human
cancers
combined
.
Diseases
Validation
Diseases presenting
"skin cancer"
symptom
dystrophic epidermolysis bullosa
erythropoietic protoporphyria
esophageal adenocarcinoma
kindler syndrome
oculocutaneous albinism
waldenström macroglobulinemia
werner syndrome
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