Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Surgical biopsies in patients with central diabetes insipidus and thickened pituitary stalks.
[erdheim-chester disease]
Thickened
pituitary
stalks
(
TPSs
)
on
magnetic
resonance
imaging
(
MRI
)
result
from
diverse
pathologies
;
therefore
,
it
is
essential
to
make
specific
diagnoses
for
clinical
decision-making
.
The
diagnoses
and
indications
for
surgical
biopsies
in
patients
with
central
diabetes
insipidus
(
CDI
)
and
TPSs
are
thoroughly
discussed
in
this
paper
.
Thirty
-
seven
patients
with
CDI
and
TPSs
were
retrospectively
reviewed
.
The
mean
age
at
the
diagnosis
of
CDI
was
29
.
0
±
15
.
9
years
(
range
8
.
0
-
63
.
3
)
,
and
the
median
duration
of
follow-up
was
5
.
5
±
2
.
8
years
(
range
0
.
7
-
13
.
0
)
.
Anterior
pituitary
hormone
deficiencies
were
documented
in
26
(
70
.
3
%
)
patients
.
All
patients
had
a
TPS
on
MRI
at
the
diagnosis
of
CDI
,
and
21
(
56
.
8
%
)
patients
exhibited
radiological
changes
during
the
follow-up
.
Of
these
21
patients
,
11
exhibited
increases
in
the
thickness
of
the
stalk
,
and
two
patients
exhibited
reversals
of
the
TPSs
.
Involvements
of
the
hypothalamus
,
pituitary
gland
,
basal
ganglia
or
supersellar
,
and
pineal
gland
were
found
in
four
,
three
,
one
,
and
1
patient
,
respectively
.
Ultimately
,
clear
diagnoses
were
established
in
17
patients
who
underwent
biopsies
,
nine
of
whom
had
germinomas
,
six
of
whom
had
Langerhans
cell
histiocytosis
,
one
of
whom
had
a
granular
cell
tumor
,
and
one
of
whom
had
Erdheim-
Chester
disease
.
Patients
with
CDI
and
TPSs
should
submit
to
periodic
clinic
follow-ups
with
serial
MRI
assessments
to
establish
anterior
pituitary
deficiencies
and
to
detect
radiological
progressions
that
are
appropriate
for
surgical
biopsies
.
Endoscopic-assisted
microsurgery
via
the
supraorbital
keyhole
approach
is
a
good
choice
for
the
biopsy
of
pituitary
stalk
lesions
.
Diseases
Validation
Diseases presenting
"pituitary gland"
symptom
aromatase deficiency
cushing syndrome
erdheim-chester disease
kallmann syndrome
triple a syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom