Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
[Immunofluorescence mapping for diagnosis of congenital epidermolysis bullosa].
[epidermolysis bullosa simplex]
The
tools
for
diagnosis
of
epidermolysis
bullosa
have
advanced
greatly
since
Hintner
's
group
introduced
antigen
mapping
as
a
diagnostic
test
for
this
family
of
genodermatoses
.
Monoclonal
or
polyclonal
antibodies
raised
against
some
of
the
specific
proteins
found
in
the
epidermis
and
basement
membrane
of
the
epidermis
have
allowed
4
types
of
epidermolysis
bullosa
de
be
identified
and
all
variants
to
be
classified
.
When
a
newborn
baby
presents
with
blisters
,
many
conditions
are
implicated
in
the
differential
diagnosis
.
Examination
under
an
optical
microscope
can
suggest
epidermolysis
bullosa
,
but
immunofluorescence
mapping
and
electron
microscopy
are
required
for
confirmation
of
the
diagnosis
and
further
classification
of
congenital
epidermolysis
bullosa
.
This
article
explains
the
importance
of
immunofluorescence
antigen
mapping
and
describes
the
methods
employed
for
classification
and
subclassification
of
epidermolysis
bullosa
.
