Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Incidence of Vesicobullous and Erosive Disorders of Neonates: Where and How Much to Worry?
[epidermolysis bullosa simplex]
OBJECTIVE
:
To
analyse
the
incidence
of
dermatoses
in
neonates
,
stress
the
importance
of
simple
noninvasive
diagnostic
procedures
with
perspective
to
actual
need
of
active
intervention
.
METHODS
:
Forty
four
neonates
with
vesicobullous
lesions
in
Departments
of
Dermatology
and
Pediatrics
were
evaluated
with
respect
to
diagnosis
,
required
treatments
and
follow
ups
.
RESULTS
:
Of
the
total
44
neonates
,
29
were
boys
and
15
girls
.
Low
birth
weight
(
weight
at
birth
less
than
2
,
500
g
as
per
WHO
criteria
)
was
seen
in
19
neonates
.
Of
the
infectious
dermatoses
,
most
common
were
pyodermas
.
Four
cases
(
9
%
)
were
diagnosed
to
be
of
staphylococcal
pyoderma
and
impetigo
and
two
cases
each
of
Group
A
Streptococcal
impetigo
and
neonatal
tinea
faciei
(
4
.
5
%
each
)
,
one
case
each
of
neonatal
candidiasis
,
neonatal
varicella
/
chickenpox
and
scabies
(
2
.
3
%
each
)
were
seen
.
Of
the
transient
skin
lesions
,
erythema
toxicum
neonatorum
was
commonest
of
all
,
being
seen
in
18
neonates
(
41
%
)
,
followed
by
four
cases
(
9
%
)
of
miliaria
crystallina
,
three
cases
of
neonatal
acne
(
6
.
8
%
)
and
two
cases
of
sucking
blisters
(
4
.
5
%
)
and
one
case
each
of
transient
neonatal
pustular
melanosis
,
epidermolysis
bullosa
simplex
,
incontinentia
pigmentii
,
eosinophilic
pustular
folliculitis
,
pemphigus
vulgaris
and
neonatal
herpes
simplex
(
2
.
3
%
each
)
were
enrolled
in
this
study
(
Fig
.
1
)
.
Fig
.
1
Piechart
showing
percentage
and
number
of
neonates
with
different
diagnostic
profiles
in
the
study
CONCLUSIONS
:
Certain
specific
considerations
have
to
be
born
in
mind
while
evaluating
and
managing
neonatal
dermatoses
.
Care
has
to
be
instituted
to
identify
accurately
infectious
diseases
and
distinguish
them
from
benign
transient
neonatal
dermatoses
.
Some
disorders
first
manifesting
during
the
neonatal
period
may
also
represent
harbingers
of
potential
problems
during
adulthood
.
Finally
,
treatment
modalities
are
instituted
taking
in
account
the
actual
diagnosis
and
judging
if
the
treatment
really
is
required
or
not
.
Diseases
Validation
Diseases presenting
"neonatal period"
symptom
alexander disease
alpha-thalassemia
benign recurrent intrahepatic cholestasis
congenital adrenal hyperplasia
congenital diaphragmatic hernia
congenital toxoplasmosis
cutaneous mastocytosis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
harlequin ichthyosis
hirschsprung disease
homocystinuria without methylmalonic aciduria
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
monosomy 21
neonatal adrenoleukodystrophy
neuralgic amyotrophy
pyruvate dehydrogenase deficiency
zellweger syndrome
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