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Cutaneous squamous cell carcinoma developing from recessive dystrophic epidermolysis bullosa: a case report and an immunohistochemical study.
[dystrophic epidermolysis bullosa]
We
describe
a
49
-
year
-old
Japanese
woman
with
cutaneous
squamous
cell
carcinoma
(
SCC
)
developing
from
recessive
dystrophic
epidermolysis
bullosa
(
RDEB
)
.
Interestingly
,
immunohistochemical
staining
revealed
dense
infiltration
of
CD
163
(
+
)
M
2
macrophages
and
numerous
Foxp
3
(
+
)
regulatory
T
cells
(
Tregs
)
around
the
tumor
.
Since
the
contribution
of
immunosuppressive
factors
(
e
.
g
.
TGFβ
)
to
the
carcinogenesis
of
SCC
from
RDEB
was
recently
reported
,
our
present
findings
suggest
one
of
the
possible
contributions
of
immunosuppressive
cells
,
such
as
CD
163
(
+
)
M
2
macrophages
and
Tregs
,
to
the
carcinogenesis
of
SCC
from
RDEB
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated