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Cutaneous squamous cell carcinoma developing from recessive dystrophic epidermolysis bullosa: a case report and an immunohistochemical study.
[dystrophic epidermolysis bullosa]
We
describe
a
49
-
year
-old
Japanese
woman
with
cutaneous
squamous
cell
carcinoma
(
SCC
)
developing
from
recessive
dystrophic
epidermolysis
bullosa
(
RDEB
)
.
Interestingly
,
immunohistochemical
staining
revealed
dense
infiltration
of
CD
163
(
+
)
M
2
macrophages
and
numerous
Foxp
3
(
+
)
regulatory
T
cells
(
Tregs
)
around
the
tumor
.
Since
the
contribution
of
immunosuppressive
factors
(
e
.
g
.
TGFβ
)
to
the
carcinogenesis
of
SCC
from
RDEB
was
recently
reported
,
our
present
findings
suggest
one
of
the
possible
contributions
of
immunosuppressive
cells
,
such
as
CD
163
(
+
)
M
2
macrophages
and
Tregs
,
to
the
carcinogenesis
of
SCC
from
RDEB
.
