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Systemic protein therapy for recessive dystrophic epidermolysis bullosa: how far are we from clinical translation?
[dystrophic epidermolysis bullosa]
In
this
issue
,
Woodley
et
al
.
report
restoration
of
anchoring
fibril
formation
and
dermal-epidermal
adherence
in
a
murine
model
of
recessive
dystrophic
epidermolysis
bullosa
(
RDEB
)
by
intravenous
injection
of
recombinant
human
type
VII
collagen
.
This
work
follows
a
previous
report
by
the
same
group
of
the
surprising
capability
of
intradermally
injected
type
VII
collagen
protein
to
reverse
RDEB
,
and
it
opens
new
therapeutic
avenues
.
Diseases
Validation
Diseases presenting
"recessive dystrophic epidermolysis bullosa"
symptom
child syndrome
dystrophic epidermolysis bullosa
junctional epidermolysis bullosa
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