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Clinical, dermoscopic and histopathological features of melanocytic nevi in dystrophic epidermolysis bullosa.
[dystrophic epidermolysis bullosa]
Epidermolysis
bullosa
(
EB
)
nevi
are
acquired
pigmented
melanocytic
lesions
which
may
have
clinical
and
dermoscopic
features
quite
similar
to
those
found
in
melanoma
.
More
detailed
information
on
this
phenomenon
is
still
lacking
.
To
evaluate
clinical
,
dermoscopic
,
and
histopathological
features
of
melanocytic
lesions
in
13
patients
with
dystrophic
EB
(
DEB
)
.
Patients
underwent
clinical
and
dermoscopic
evaluation
.
Suspicious
lesions
were
excised
and
examined
microscopically
.
There
were
12
cases
of
recessive
DEB
and
one
of
dominant
DEB
.
Five
patients
were
men
;
8
were
women
;
the
ages
ranged
from
2
to
27
years
old
.
All
patients
had
at
least
2
atypical
melanocytic
lesions
.
Two
of
the
5
biopsied
patients
showed
an
atypical
nevus
or
lentigo
on
histopathological
examination
.
We
observed
a
high
incidence
of
large
and
atypical
melanocytic
lesions
in
DEB
patients
.
Although
the
exact
explanation
for
this
is
still
unclear
,
it
seems
that
re
-epithelization
and
the
chronic
inflammatory
process
may
stimulate
the
proliferation
of
melanocytes
,
as
well
as
the
emergence
of
lesions
with
atypical
clinical
and
dermoscopic
features
.
As
an
unequivocal
discrimination
from
malignant
melanoma
in
vivo
is
not
always
possible
,
regular
clinical
follow-up
and
histopathological
evaluation
of
suspicious
lesions
in
EB
patients
are
mandatory
.
Diseases
Validation
Diseases presenting
"nevus"
symptom
child syndrome
cowden syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
gm1 gangliosidosis
kabuki syndrome
lamellar ichthyosis
liposarcoma
malignant atrophic papulosis
oculocutaneous albinism
proteus syndrome
sneddon syndrome
This symptom has already been validated