Rare Diseases Symptoms Automatic Extraction
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Clinical, dermoscopic and histopathological features of melanocytic nevi in dystrophic epidermolysis bullosa.
[dystrophic epidermolysis bullosa]
Epidermolysis
bullosa
(
EB
)
nevi
are
acquired
pigmented
melanocytic
lesions
which
may
have
clinical
and
dermoscopic
features
quite
similar
to
those
found
in
melanoma
.
More
detailed
information
on
this
phenomenon
is
still
lacking
.
To
evaluate
clinical
,
dermoscopic
,
and
histopathological
features
of
melanocytic
lesions
in
13
patients
with
dystrophic
EB
(
DEB
)
.
Patients
underwent
clinical
and
dermoscopic
evaluation
.
Suspicious
lesions
were
excised
and
examined
microscopically
.
There
were
12
cases
of
recessive
DEB
and
one
of
dominant
DEB
.
Five
patients
were
men
;
8
were
women
;
the
ages
ranged
from
2
to
27
years
old
.
All
patients
had
at
least
2
atypical
melanocytic
lesions
.
Two
of
the
5
biopsied
patients
showed
an
atypical
nevus
or
lentigo
on
histopathological
examination
.
We
observed
a
high
incidence
of
large
and
atypical
melanocytic
lesions
in
DEB
patients
.
Although
the
exact
explanation
for
this
is
still
unclear
,
it
seems
that
re
-epithelization
and
the
chronic
inflammatory
process
may
stimulate
the
proliferation
of
melanocytes
,
as
well
as
the
emergence
of
lesions
with
atypical
clinical
and
dermoscopic
features
.
As
an
unequivocal
discrimination
from
malignant
melanoma
in
vivo
is
not
always
possible
,
regular
clinical
follow-up
and
histopathological
evaluation
of
suspicious
lesions
in
EB
patients
are
mandatory
.