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Disinfectants/antiseptics in the management of guinea worm ulcers in the rural areas.
[dracunculiasis]
The
effectiveness
of
trichlorophenol
(
TCP
)
,
chlorhexidine
gluconate
plus
cetrimide
(
Savlon
)
and
Izal
in
inhibiting
the
growth
of
bacterial
isolates
from
guinea
worm
ulcers
was
investigated
.
Using
an
adaptation
of
the
method
of
Russell
and
Furr
(
Russell
,
A
.
D
.
,
Furr
,
J
.
R
.
,
1977
.
The
antibacterial
activity
of
a
new
chloroxylenol
preparation
containing
ethylenediamine
tetraacetic
acid
.
J
.
Appl
.
Bacteriol
.
43
,
253
-
260
)
the
minimum
inhibitory
concentration
(
MIC
)
values
of
the
three
anti-microbial
agents
for
each
of
the
isolated
bacteria
was
determined
.
Water
drawn
from
the
rural
guinea
worm
endemic
sites
was
autoclaved
and
used
for
the
various
dilutions
of
the
anti-microbial
agents
.
At
the
manufactures
'
recommended
use-dilutions
in
cases
of
wounds
/
cuts
/
sores
,
Savlon
showed
greater
effectiveness
than
Izal
and
TCP
in
this
order
.
Probable
organic
and
inorganic
inhibitors
in
water
that
is
usually
employed
in
diluting
anti-microbial
agents
in
the
rural
areas
for
the
dressing
of
guinea
worm
ulcers
very
likely
had
greatest
effect
(
s
)
on
TCP
and
least
effect
(
s
)
on
Savlon
.
