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Chemistry and pharmacology of neglected helminthic diseases.
[dracunculiasis]
Neglected
helminthic
diseases
cause
many
social
,
economic
and
health
care
challenges
in
developing
countries
.
The
high
number
of
patients
suffering
from
these
parasitic
infections
and
the
lack
of
sufficient
treatment
options
represent
severe
problems
.
Research
on
new
drugs
and
therapies
to
meet
this
urgent
requirement
has
to
be
intensified
.
This
review
focuses
on
infections
caused
by
four
helminthic
parasites
,
which
have
been
declared
as
neglected
diseases
by
the
World
Health
Organization
:
namely
drancunculiasis
,
lymphatic
filariasis
,
onchoceriasis
,
and
schistosomiasis
.
They
show
a
considerable
overlap
in
their
world-
wide
prevalence
and
treatment
strategies
.
Nevertheless
,
treatment
is
not
without
complications
.
The
most
efficient
lymphatic
filariasis
drug
,
diethylcarbamazine
,
causes
severe
adverse
effects
in
onchocerciasis
patients
and
completely
fails
in
the
treatment
of
drancunculiasis
.
In
this
review
,
we
discuss
these
incongruities
at
the
molecular
and
cellular
level
.
Furthermore
,
established
or
investigational
drug
combination
regimens
are
highlighted
.
In
the
past
years
,
progress
has
been
made
in
the
area
of
schistosomiasis
and
onchocerciasis
.
The
molecular
biology
of
underlying
mechanisms
,
signalling
pathways
and
related
targets
affected
by
drug
therapy
are
discussed
in
detail
.
Finally
,
successful
treatment
strategies
and
remaining
future
challenges
are
summarized
.
Diseases
Validation
Diseases presenting
"lymphatic filariasis"
symptom
dracunculiasis
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