Rare Diseases Symptoms Automatic Extraction
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Our Project
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Neglected tropical diseases: survey and geometry of randomised evidence.
[dracunculiasis]
To
assess
the
quantity
and
distribution
of
evidence
from
randomised
controlled
trials
for
the
treatment
of
the
major
neglected
tropical
diseases
and
to
identify
gaps
in
the
evidence
with
network
analysis
.
Systematic
review
and
network
analysis
.
Cochrane
Central
Register
of
Controlled
Trials
and
PubMed
from
inception
to
31
August
2011
.
Randomised
controlled
trials
that
examined
treatment
of
16
neglected
tropical
diseases
or
complications
thereof
published
in
English
,
French
,
Spanish
,
Portuguese
,
German
,
or
Dutch
.
We
identified
971
eligible
randomised
trials
.
Leishmaniasis
(
184
trials
,
23
,
039
participants
)
and
geohelminth
infections
;
160
trials
,
46
,
887
participants
)
were
the
most
studied
,
while
dracunculiasis
(
nine
trials
,
798
participants
)
and
Buruli
ulcer
(
five
trials
,
337
participants
)
were
least
studied
.
Relative
to
its
global
burden
of
disease
,
lymphatic
filariasis
had
the
fewest
trials
and
participants
.
Only
11
%
of
trials
were
industry
funded
.
Either
a
single
trial
or
trials
with
fewer
than
100
participants
comprised
the
randomised
evidence
for
first
or
second
line
treatments
for
Buruli
ulcer
,
human
African
trypanosomiasis
,
American
trypanosomiasis
,
cysticercosis
,
rabies
,
echinococcosis
,
New
World
cutaneous
leishmaniasis
,
and
each
of
the
foodborne
trematode
infections
.
Among
the
10
disease
categories
with
more
than
40
trials
,
five
lacked
sufficient
head
to
head
comparisons
between
first
or
second
line
treatments
.
There
is
considerable
variation
in
the
amount
of
evidence
from
randomised
controlled
trials
for
each
of
the
16
major
neglected
tropical
diseases
.
Even
in
diseases
with
substantial
evidence
,
such
as
leishmaniasis
and
geohelminth
infections
,
some
recommended
treatments
have
limited
supporting
data
and
lack
head
to
head
comparisons
.
Diseases
Validation
Diseases presenting
"trials with fewer than 100 participants comprised the randomised evidence for first or second line treatments for buruli ulcer"
symptom
dracunculiasis
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