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Heart failure, ventricular dysfunction and risk factor prevalence in Australian Aboriginal peoples: the Heart of the Heart Study.
[acute rheumatic fever]
Limited
strategies
have
been
developed
to
evaluate
and
address
the
alarming
discrepancy
in
early
mortality
between
Indigenous
and
non-
Indigenous
populations
.
T
o
assess
heart
failure
(
HF
)
,
HF
risk
factors
and
document
cardiac
characteristics
in
an
Australian
Aboriginal
population
.
A
dults
were
enrolled
across
six
Aboriginal
communities
in
Central
Australia
.
They
undertook
comprehensive
cardiovascular
assessments
,
including
echocardiography
,
to
determine
HF
status
,
asymptomatic
ventricular
dysfunction
and
underlying
risk
factor
profile
.
Of
436
participants
(
mean
age
44
±
14
years
;
64
%
women
)
enrolled
,
5
.
3
%
(
95
%
CI
3
.
2
%
to
7
.
5
%
)
were
diagnosed
with
HF
,
only
35
%
of
whom
had
a
pre-existing
HF
diagnosis
.
Asymptomatic
left
ventricular
dysfunction
(
ALVD
)
was
seen
in
13
%
(
95
%
CI
9
.
4
%
to
15
.
7
%
)
of
the
population
.
Estimates
of
HF
risk
factor
prevalence
were
as
follows
:
body
mass
index
(
BMI
)
≥
30
kg
/
m
(
2
)
42
%
,
hypertension
41
%
,
diabetes
mellitus
40
%
,
coronary
artery
disease
(
CAD
)
7
%
and
history
of
acute
rheumatic
fever
or
rheumatic
heart
disease
7
%
.
In
logistic
regression
analysis
(
after
adjustment
for
age
and
gender
)
,
HF
was
associated
with
CAD
(
OR
=
9
.
6
,
p
<
0
.
001
)
,
diabetes
(
OR
=
5
.
4
,
p
=
0
.
002
)
,
hypertension
(
OR
=
4
.
8
,
p
=
0
.
006
)
,
BMI
≥
30
kg
/
m
(
2
)
(
OR
=
2
.
9
,
p
=
0
.
02
)
,
acute
rheumatic
fever
or
rheumatic
heart
disease
(
OR
=
5
.
6
,
p
=
0
.
001
)
and
B-
type
natriuretic
peptide
(
OR
=
1
.
02
,
p
<
0
.
001
)
.
The
burden
of
HF
,
ALVD
and
risk
factors
in
this
population
was
extremely
high
.
This
study
highlights
potentially
modifiable
targets
on
which
to
focus
resources
and
screening
strategies
to
prevent
HF
in
this
high
-risk
Indigenous
population
.
Diseases
Validation
Diseases presenting
"hypertension"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
aniridia
aromatase deficiency
cadasil
child syndrome
cohen syndrome
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cushing syndrome
cystinuria
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
fabry disease
familial hypocalciuric hypercalcemia
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
holt-oram syndrome
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
kallmann syndrome
kindler syndrome
lamellar ichthyosis
lymphangioleiomyomatosis
pendred syndrome
primary effusion lymphoma
scrub typhus
severe combined immunodeficiency
sneddon syndrome
typhoid
von hippel-lindau disease
well-differentiated liposarcoma
werner syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
This symptom has already been validated