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Transforming growth factor-beta1 negatively regulates crystallin expression in teeth.
[dentin dysplasia]
Previously
,
we
have
reported
that
targeted
overexpression
of
transforming
growth
factor
(
TGF
)
beta
1
in
the
teeth
of
the
transgenic
mice
(
dTGF-
beta
1
)
results
in
a
novel
tooth
phenotype
phenomimicking
the
most
prevalent
tooth
disorders
in
human
.
This
phenotype
was
associated
with
discoloration
and
attrition
of
teeth
due
to
defective
mineralization
.
Here
,
we
report
a
novel
expression
of
crystallin
family
members
in
developing
mouse
teeth
and
its
regulation
by
TGF-
beta
1
in
these
transgenic
mice
.
AlphaB-
and
beta
-crystallins
were
found
to
be
elevated
in
dTGF-
beta
1
mouse
teeth
,
whereas
gamma-crystallin
(
gammaB
,
gammaC
,
and
gammaF
)
,
a
marker
of
cell
differentiation
,
was
significantly
reduced
.
Because
crystallins
are
believed
to
be
stress-related
proteins
,
their
expression
in
teeth
implicates
them
in
a
similar
role
because
teeth
are
constantly
subjected
to
physical
friction
and
temperature
fluctuations
.
Diseases
Validation
Diseases presenting
"growth factor"
symptom
22q11.2 deletion syndrome
achondroplasia
adrenal incidentaloma
aniridia
cadasil
cholangiocarcinoma
coats disease
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
dystrophic epidermolysis bullosa
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
holt-oram syndrome
inclusion body myositis
kallmann syndrome
krabbe disease
liposarcoma
lymphangioleiomyomatosis
oculocutaneous albinism
oral submucous fibrosis
pleomorphic liposarcoma
primary effusion lymphoma
primary hyperoxaluria type 1
severe combined immunodeficiency
systemic capillary leak syndrome
von hippel-lindau disease
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
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