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A random Abstract
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MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21.
[dentin dysplasia]
Substantial
progress
has
been
made
regarding
the
molecular
etiology
of
the
dentin
diseases
dentinogenesis
imperfecta
types
II
and
III
,
and
dentin
dysplasia
type
II
.
Genetic
linkage
studies
have
identified
the
critical
loci
for
these
diseases
on
human
chromosome
4
q
21
.
Located
within
an
overlapping
segment
of
these
disease
loci
is
a
dentin
/
bone
gene
cluster
that
includes
osteopontin
,
bone
sialoprotein
,
dentin
matrix
protein
1
,
dentin
sialophosphoprotein
,
and
a
new
gene
MEPE
also
known
as
OF
45
,
renamed
osteoregulin
.
In
this
paper
,
we
report
the
location
of
MEPE
/
OF
45
in
relationship
to
the
other
members
of
the
dentin
/
bone
gene
cluster
as
well
as
the
genomic
organization
of
the
human
gene
.
For
the
first
time
,
MEPE
/
OF
45
expression
was
shown
in
dental
tissue
,
in
particular
odontoblasts
,
by
reverse-transcription
polymerase
chain
reaction
(
RT-PCR
)
amplification
and
characterization
of
a
partial
mouse
cDNA
.
Our
data
provide
the
first
evidence
that
MEPE
/
OF
45
is
expressed
during
odontogenesis
and
should
be
considered
as
a
candidate
gene
for
dentin
structural
diseases
mapping
to
human
chromosome
4
q
21
.
Diseases
Validation
Diseases presenting
"first evidence"
symptom
congenital adrenal hyperplasia
dentin dysplasia
esophageal adenocarcinoma
fabry disease
homocystinuria without methylmalonic aciduria
krabbe disease
liposarcoma
phenylketonuria
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