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A random Abstract
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MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21.
[dentin dysplasia]
Substantial
progress
has
been
made
regarding
the
molecular
etiology
of
the
dentin
diseases
dentinogenesis
imperfecta
types
II
and
III
,
and
dentin
dysplasia
type
II
.
Genetic
linkage
studies
have
identified
the
critical
loci
for
these
diseases
on
human
chromosome
4
q
21
.
Located
within
an
overlapping
segment
of
these
disease
loci
is
a
dentin
/
bone
gene
cluster
that
includes
osteopontin
,
bone
sialoprotein
,
dentin
matrix
protein
1
,
dentin
sialophosphoprotein
,
and
a
new
gene
MEPE
also
known
as
OF
45
,
renamed
osteoregulin
.
In
this
paper
,
we
report
the
location
of
MEPE
/
OF
45
in
relationship
to
the
other
members
of
the
dentin
/
bone
gene
cluster
as
well
as
the
genomic
organization
of
the
human
gene
.
For
the
first
time
,
MEPE
/
OF
45
expression
was
shown
in
dental
tissue
,
in
particular
odontoblasts
,
by
reverse-transcription
polymerase
chain
reaction
(
RT-PCR
)
amplification
and
characterization
of
a
partial
mouse
cDNA
.
Our
data
provide
the
first
evidence
that
MEPE
/
OF
45
is
expressed
during
odontogenesis
and
should
be
considered
as
a
candidate
gene
for
dentin
structural
diseases
mapping
to
human
chromosome
4
q
21
.
Diseases
Validation
Diseases presenting
"first time"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
adrenomyeloneuropathy
alpha-thalassemia
aniridia
aromatase deficiency
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
classical phenylketonuria
congenital adrenal hyperplasia
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dentin dysplasia
dentinogenesis imperfecta
dracunculiasis
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
fabry disease
familial mediterranean fever
gm1 gangliosidosis
harlequin ichthyosis
heparin-induced thrombocytopenia
hirschsprung disease
hodgkin lymphoma, classical
holt-oram syndrome
hydrocephalus with stenosis of the aqueduct of sylvius
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
malignant atrophic papulosis
megacystis-microcolon-intestinal hypoperistalsis syndrome
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
omenn syndrome
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
phenylketonuria
primary effusion lymphoma
primary hyperoxaluria type 1
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
trochlear dysplasia
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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