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The effect of lathyrism on dentin structure of the rat incisors: a morphometric and scanning electron microscopic investigation.
[dentin dysplasia]
The
present
study
was
designed
to
study
the
effect
of
beta
-aminopropionitrile
(
beta
-
APN
)
,
present
in
Lathyrus
sativus
grass
pea
consumed
in
drought
prone
areas
,
on
dentin
of
the
continuously
erupting
rat
incisors
.
Eighteen
adult
male
rats
were
used
.
In
the
experimental
group
(
18
rats
)
,
lathyrism
was
induced
by
a
once
daily
subcutaneous
administration
of
beta
-
APN
for
40
days
.
The
maxillary
and
mandibular
incisors
were
examined
ultrastructurally
and
morphometrically
.
The
mean
number
of
patent
tubules
,
the
mean
area
,
perimeter
and
the
area
percent
of
the
tubules
were
analyzed
.
Ultrastructurally
,
the
dentinal
tubules
of
both
coronal
and
radicular
dentin
in
the
lathyritic
group
were
narrower
or
even
obliterated
compared
with
those
in
the
control
.
The
coronal
and
radicular
dentin
of
the
lathyritic
group
exhibited
an
irregular
lattice
of
non-mineralized
small
branching
collagen
fibrils
obliterating
the
dentinal
tubules
.
The
mean
number
of
patent
tubules
in
the
control
and
lathyritic
groups
revealed
an
insignificant
difference
.
The
mean
area
of
the
tubules
showed
a
statistically
significant
difference
in
lathyritic
radicular
dentin
(
P
=
0
.
0353
)
.
The
percentage
of
the
total
surface
area
of
the
dentinal
tubules
significantly
decreased
in
the
radicular
dentin
of
the
lathyritic
group
(
P
=
0
.
024
)
.
These
findings
indicated
a
deleterious
effect
of
lathyrism
on
dentin
,
with
a
possible
negative
impact
on
developing
teeth
integrity
.
Diseases
Validation
Diseases presenting
"total surface area of the dentinal tubules"
symptom
dentin dysplasia
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