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NY-ESO-1 expression in synovial sarcoma and other mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and differential diagnosis.
[dedifferentiated liposarcoma]
A
promising
targeted
therapy
against
NY
-ESO-
1
(
CTAG
1
B
)
using
genetically
modified
T
-
cells
in
synovial
sarcomas
was
recently
demonstrated
in
a
clinical
trial
at
the
NCI
.
To
investigate
the
role
of
NY
-ESO-
1
immunohistochemistry
in
patient
selection
and
gain
better
insight
into
the
incidence
of
NY
-ESO-
1
expression
in
synovial
sarcomas
and
other
mesenchymal
tumors
,
we
evaluated
NY
-ESO-
1
expression
by
immunohistochemistry
in
417
tumors
.
This
collection
of
samples
included
:
50
SS
18
/
SSX
1
/
2
fusion
positive
synovial
sarcomas
,
155
gastrointestinal
stromal
tumors
(
GIST
)
,
135
other
spindle
cell
sarcomas
as
well
as
77
other
sarcomas
(
chondrosarcoma
,
osteosarcoma
,
dedifferentiated
liposarcoma
,
alveolar
soft
part
sarcoma
,
rhabdomyosarcoma
,
angiosarcoma
,
malignant
mesothelioma
,
and
Ewing
's
sarcoma
)
.
We
report
that
76
%
of
synovial
sarcomas
expressed
NY
-ESO-
1
in
a
strong
and
diffuse
pattern
(
2
-
3
+
,
>
50
-
70
%
of
tumor
cells
)
.
In
contrast
,
only
rare
cases
of
other
spindle
cell
mesenchymal
tumor
expressed
NY
-ESO-
1
(
GIST
(
2
/
155
)
,
malignant
peripheral
nerve
sheath
tumors
(
1
/
34
)
,
and
dermatofibrosarcoma
protuberans
(
2
/
20
)
)
.
Individual
cases
of
other
sarcomas
(
angiosarcoma
,
malignant
mesothelioma
,
chondrosarcoma
,
osteosarcoma
,
dedifferentiated
liposarcoma
,
alveolar
soft
part
sarcoma
,
and
Ewing
's
sarcoma
)
were
positive
for
NY
-ESO-
1
.
However
,
no
positive
cases
were
identified
amongst
our
cohort
of
leiomyosarcomas
(
0
/
24
)
,
hemangiopericytoma
/
solitary
fibrous
tumors
(
0
/
40
)
,
and
cellular
schwannomas
(
0
/
17
)
.
In
summary
,
we
find
that
NY
-ESO-
1
is
strongly
and
diffusely
expressed
in
a
majority
of
synovial
sarcomas
,
but
only
rarely
in
other
mesenchymal
lesions
.
Beyond
its
role
in
patient
selection
for
targeted
therapy
,
immunohistochemistry
for
NY
-ESO-
1
may
be
diagnostically
useful
for
the
distinction
of
synovial
sarcoma
from
other
spindle
cell
neoplasms
.
Diseases
Validation
Diseases presenting
"solitary fibrous tumors"
symptom
adrenal incidentaloma
dedifferentiated liposarcoma
liposarcoma
well-differentiated liposarcoma
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